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Localization exclusion of the HL-A genes from the short arm of human chromosome 5

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Summary

A cri du chat patient with deletion of more than 3/4 of the short arm of one chromosome 5 was found to be heterozygous at both of the closely linked HL-A gene loci, thus demonstrating that the HL-A genes cannot be located on the missing segment.

Zusammenfassung

Bei einem Patienten mit Cri du chat-Syndrom und einer Chromosomendefizienz, die mehr als 3/4 des kurzen Armes eines Chromosoms 5 umfaßt, wurde Heterozygotie an beiden der enggekoppelten HL-A-Gene festgestellt. Damit können die HL-A-Gene nicht auf dem deletierten Abschmitt lokalisiert sein.

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References

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Supported by the Deutsche Forschungsgemeinschaft.

Supported by The Danish State Research Foundation and Einar Willumsen's Foundation.

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Bender, K., Schindera, F. & Kissmeyer-Nielsen, F. Localization exclusion of the HL-A genes from the short arm of human chromosome 5. Hum Genet 11, 78–80 (1970). https://doi.org/10.1007/BF00296309

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Gene Locus
  • Human Chromosome
  • Localization Exclusion