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Archives of Toxicology

, Volume 53, Issue 4, pp 297–316 | Cite as

Intoxication with four synthetic pyrethroids fails to show any correlation between neuromuscular dysfunction and neurobiochemical abnormalities in rats

  • G. P. Rose
  • A. J. Dewar
Article

Abstract

The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfunction was assessed by means of the inclined plane test and peripheral nerve damage by reference to β-glucuronidase and β-galactosidase activity increases in nerve tissue homogenates from treated and control animals. A transient functional impairment was found in animals treated with any one of the four pyrethroids tested and in all cases this was maximal at the end of the 7 day subacute dosing regimen. Significant increases in β-glucuronidase and β-galactosidase were found 3–4 weeks after the start of dosing in the distal portion of the sciatic/posterior tibial nerves from permethrin, cypermethrin, and deltamethrin treated animal; but no changes were found in remesthrin-dosed animals. It is concluded therefore, that there is no direct correlation between the time-course of the neuromuscular dysfunction and the neurobiochemical changes. This suggests that these pyrethroids have at least two distinct actions — a short-term pharmacological effect and at near-lethal dose levels a more chronic neurotoxic effect that results in sparse axonal nerve damage.

Key words

Pyrethroids Neuromuscular dysfunction Inclined plane test Peripheral nerve damage Neurochemical correlates β-Glucuronidase β-Galactosidase Sciatic/posterior tibial nerve 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • G. P. Rose
    • 1
  • A. J. Dewar
    • 1
  1. 1.Shell Research Limited, Sittingbourne Research CentreSittingbourneEngland

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