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Neuronal counts from four cortical regions of alcoholic brains

Summary

Neuronal loss from the frontal superior cortex of the brains of alcoholics has recently been documented. In addition to this, a reduction in the mean neuronal area was also seen in the frontal and motor cortices. This suggested a regional specificity of neuronal damage in the brains of alcoholics. Further quantitation of other cortical regions of the same cases as used in the above study has been performed. The frontal cingulate and temporal cortices were examined and there was found to be no significant alteration in the number of neurons when compared to a control population. There was, however, a significant reduction in the mean size of the neuronal soma in the frontal cingulate cortex (P < 0.05). These data support the hypothesis of regional variations in the severity of cerebral cortical damage in alcoholism with shrinkage of neurons in most regions examined but neuronal loss only in the superior frontal gyrus.

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References

  1. 1.

    Alvarez MG, Stoltenburg-Didinger G, Aruffo C (1986) “Ageing” of spine morphology in hippocampal pyramidal cells of rats prenatally exposed to ethanol — A Golgi study. Int Congr Neuropathol 10:282

  2. 2.

    Anderson JM, Hubbard BM, Coghill GR, Slidders W (1983) The effect of advanced age on the neurone content of the cerebral cortex. J Neurol Sci 58:233–244

  3. 3.

    Brody H (1955) Organization of the cerebral cortex III. A study of aging in the human cerebral cortex. J Comp Neurol 102:511–556

  4. 4.

    Carlen PL, Wilkinson DA, Wortzman G, Holgate R, Cordingley J, Lee MA, Huszar L, Moddel G, Singh R, Kiraly L, Rankin JG (1981) Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology 31:377–385

  5. 5.

    Corbett D, Harper C (1988) A Golgi study of the cortical neurones in alcoholics. Neurosci Lett 1988 [Suppl] 30:s59

  6. 6.

    Courville CB (1955) Effects of alcohol on the nervous system of man. San Lucas Press, Los Angeles

  7. 7.

    Davies DL, Smith DE (1981) A Golgi study of mouse hippocampal CA1 pyramidal neurones following perinatal ethanol exposure. Neurosci Lett 26:49–54

  8. 8.

    Ferrer I, Fabregues I, Pineda M, Gracia I, Ribalta T (1984) A Golgi study of cerebellar atrophy in human chronic alcoholism. Neuropathol Appl Neurobiol 10:245–253

  9. 9.

    Harper CG (1983) The incidence of Wernicke's encephalopathy in Australia — a neuropathological study. J Neurol Neurosurg Psychiatry 46:593–598

  10. 10.

    Harper CG, Kril JJ, Holloway RL (1985) Brain shirinkage in chronic alcoholics — a pathological study. Br Med J 290:501–504

  11. 11.

    Harper C, Kril J (1987) Are we drinking our neurones away? Br Med J 294:534–536

  12. 12.

    Harper CG, Kril JJ, Daly JM (1987) The specific gravity of the brains of alcoholic and control patients: a pathological study. Br J Addict 82:1349–1354

  13. 13.

    Harper CG, Kril JJ, Daly JM (1988) Brain shrinkage in alcoholics is not caused by changes in hydration: a pathological study. J Neurol Neurosurg Psychiatry 51:124–127

  14. 14.

    Haug H, Kuhl S, Mecke E, Sass N, Wasner K (1984) The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of human brain. J Hirnforsch 25:353–374

  15. 15.

    Jacobson RR, Lishman WA (1987) Selective memory loss and global intellectual deficits in alcoholic Korsakoff's syndrome. Psychol Med 17:649–655

  16. 16.

    Lishman WA, Jacobson RR, Acker C (1987) Brain damage in alcoholism: current concepts. Acta Med Scand [Suppl] 717:5–17

  17. 17.

    Mountjoy CQ, Roth M, Evans NJR, Evans HM (1983) Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 4:1–11

  18. 18.

    Pentney RJ, Cotter JR, Abel EL (1984) Quantitative measures of mature neuronal morphology after in utero ethanol exposure. Neurobehav Toxicol Teratol 6:59–65

  19. 19.

    Ron MA (1983) The alcoholic brain: CT and psychological findings. Psychol Med [Monogr Suppl] 3:1–33

  20. 20.

    Tavares MA, Paula-Barbosa MM (1983) Lipofuscin granules in Purkinje cells after long-term alcohol consumption in rats. Alcoholism: Clin Exp Res 7:302–306

  21. 21.

    Terry RD, Peck A, DeTeresa R, Schechter R, Horoupian DS (1981) Some morphological aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10:184–192

  22. 22.

    Terry RD, DeTeresa R, Hansen LA (1987) Neocortical cell counts in normal human adult aging. Ann Neurol 21:530–539

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Author information

Correspondence to C. G. Harper.

Additional information

Supported by grants from the National Health & Medical Research Council (No. 870564), the Clive and Vera Ramiacotti Foundations and Sandoz Foundation for Gerontological Research

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Kril, J.J., Harper, C.G. Neuronal counts from four cortical regions of alcoholic brains. Acta Neuropathol 79, 200–204 (1989). https://doi.org/10.1007/BF00294379

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Key words

  • Alcohol
  • Brain
  • Neuronal counts
  • Human