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The effect of calcium and magnesium ions on urinary urokinase and sialidase activity

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The effect of a promoter (calcium) and an inhibitior (magnesium) of urolithiasis was spectrophotometrically studied on urokinase (0.45 IU) and sialidase (5 mM). Although these mineral did not affect the sialidase activity, total inhibition of urokinase activity was observed with either 0.05 M calcium chloride or 0.1 M magnesium chloride. This observation might explain why calcium and magnesium respectively function as a promoter and an inhibitor of stone formation.

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van Aswegen, C.H., Dirksen van Sckalckwyk, J.C., du Toit, P.J. et al. The effect of calcium and magnesium ions on urinary urokinase and sialidase activity. Urol. Res. 20, 41–44 (1992). https://doi.org/10.1007/BF00294333

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Key words

  • Calcium
  • Kidney stones
  • Magnesium
  • Plasmin
  • Sialidase
  • Urokinase