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Radionuclide detection of mild valvular regurgitation: Its significance as assessed by Doppler sonography


Radionuclide ventriculography (RNV) indices of regurgitation, Fourier amplitude ratio (FAR) and additional RNV variables were prospectively compared to Doppler echocardiography (DE) in 108 consecutive patients with no or mild left ventricular regurgitation to assess RNV accuracy in detecting regurgitation in patients with different cardiac disorders. Exclusion of left ventricular or tricuspid regurgitation allowed investigation of the FAR range at rest and during exercise in a sufficiently large appropriate reference group without regurgitation. FAR, as well as other RNV variables, failed to provide more information for the diagnosis of mild (clinically irrelevant) left ventricular regurgitation than the diagnosis upon admission alone. Despite the superiority of DE as a gold standard in the detection of mild regurgitation, at present evaluation of RNV regurgitation indices might be the only method to discover regurgitation arising during dynamic exercise.

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  1. Adhar GC, Nanda NC (1984) Doppler Echocardiography: Part II: Adult valvular heart disease. Echocardiography 1:219–241

  2. Alderson PO (1982) Radionuclide quantification of valvular regurgitation. J Nucl Med 23:851–855

  3. Bauer R, Haluszczynski I, Langhammer H, Bachmann W (1983) In vivo/in vitro labeling of red blood cells with 99m-Tc. Eur J Nucl Med 8:218–222

  4. Berthout P, Cardot JC, Baud M, Faivre R, Verdenet J, Bidet AC, Bassand JP, Bidet R, Maurat JP (1984) Factors influencing the quantification of valvular regurgitation by gated equilibirium radionuclide angiography. Eur J Nucl Med 9:112–114

  5. Blumlein S, Bouchard A, Schiller NB, Dae M, Byrd B, Ports T, Botvinick E (1986) Quantitation of mitral regurgitation by Doppler echocardiography. Circulation 74:306–314

  6. Dittmann H, Karsch KR, Seipel L (1986) Diagnosis and quantification of aortic regurgitation by Doppler echocardiography in patients with aortic stenosis and mitral valve disease. Z Kardiol 75:522–527

  7. Fridrich L, Gassner A (1984) Quantification of valvular regurgitation. Eur J Nucl Med 9:566

  8. Maddahi J, Berman DS, Matsuoka DT, Wasman AD, Stankus K, Forrester J, Swan HJ (1979) A new technique for assessing right ventricular ejection fraction using rapid multiple-gated equilibrium cardiac blood pool scintigraphy. Circulation 60:581–589

  9. Makler PT Jr, McCarthy DM, Velchik MG, Goldstein HA, Alavi A (1983) Fourier amplitude ratio: a new way to assess valvular regurgitation. J Nucl Med 24:204–207

  10. Nicod P, Corbett JR, Firth BG, Dehmer GJ, Izquierdo C, Markham RV Jr, Hillis LD, Willerson JT, Lewis SE (1982) Radionuclide techniques for valvular regurgitant index: Comparison in patients with normal and depressed ventricular function. J Nucl Med 23:763–769

  11. Novack H, Machac J, Horowitz SF (1985) Inversion of the radionuclide regurgitant index in right-sided valvular regurgitation. Eur J Nucl Med 11:205–209

  12. Ormerod OJM, Barber RW, Stone DL, Wraight EP, Petch MC (1986) A comparison of radionuclide methods of evaluating aortic regurgitation with observations on the effect of exercise and symptoms. Eur J Nucl Med 12:72–76

  13. Reske SN, heck I, Kropp J, Mattern H, Ledda R, Knopp R, Winkler C (1985) Captopril mediated decrease of aortic regurgitation. Br Heart J 54:415–419

  14. Rigo P, Alderson PO, Robertson RM, Becker LC, Wagner HN Jr (1979) Measurement of aortic and mitral regurgitation by gated cardiac blood pool scans. Circulation 60:306

  15. Underwood SR, Klipstein RH, Firmin DN, Fox KM, Poole-Wilson PA, Rees RSO, Longmore DB (1986) Magnetic resonance assessment of aortic and mitral regurgitation. Br Heart J 56:455–462

  16. Voth E, Sciagra R, Tebbe U, Schicha H (1986) Vergleich verschiedener Verfahren zur Bestimmung von Regurgitationsfraktionen mit der Äquilibrium-Radionuklidventrikulographie. In: Höfer R, Bergmann H (eds) Radioaktive Isotope in Klinik und Forschung 18. Egermann, Vienna pp 257–263

  17. Zaret BL, Battler A, Berger HJ, Bodenheimer MM, Borer IS, Brochier M, Hugenholtz PG, Neufeld HN, Pfister ME (1984) Report of the joint international society and federation of cardiology/WHO task force on nuclear cardiology. Eur Heart J 51:850–863

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Correspondence to Leo Fridrich.

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Fridrich, L., Weihs, W., Sommer, G. et al. Radionuclide detection of mild valvular regurgitation: Its significance as assessed by Doppler sonography. Eur J Nucl Med 14, 125–130 (1988).

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Key words

  • Regurgitation
  • Fourier amplitude ratio
  • Doppler echocardiography