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Molecular and General Genetics MGG

, Volume 125, Issue 1, pp 91–98 | Cite as

Extrachromosomal inheritance of paromomycin resistance in Saccharomyces cerevisiae

Genetic and biochemical characterization of mutants
  • Regina Kutzleb
  • Rudolf J. Schweyen
  • Fritz Kaudewitz
Article

Summary

In Saccharomyces cerevisiae, mutants were isolated which show high resistance to the aminoglycoside paromomycin. Amino acid incorporation of mitochondria isolated from such mutant strains proved also to be paromomycin resistant. All of them are cross-resistant to the structurally related antibiotic neomycin. Three independent methods revealed the resistance to be extrachromosomally, presumably mitochondrially inherited.

Keywords

Saccharomyces Cerevisiae Saccharomyces Mutant Strain High Resistance Aminoglycoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Regina Kutzleb
    • 1
  • Rudolf J. Schweyen
    • 1
  • Fritz Kaudewitz
    • 1
  1. 1.Institut für Genetik der Universität MünchenMunchenGermany

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