Bidirectional termination of chromosome replication in Escherichia coli
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Autoradiography was used to study the termination of replication of the circular chromosome of Escherichia coli. The experiments were conducted with cells in which termination occurred with a moderate amount of synchrony. Grain tracks were observed that demonstrated the approach at the replication terminus of the two replication forks involved in bidirectional replication. Other grain tracks were formed by replication forks that had met at the replication terminus. The frequency at which these patterns were observed indicates that most, if not all, terminations occur with both replication forks reaching the terminus at approximately the same time.
KeywordsEscherichia Coli Moderate Amount Replication Fork Circular Chromosome Chromosome Replication
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- Kuempel, P. L., Prescott, D. M., Maglothin, P.: Autoradiographic demonstration of bidirectional replication in Escherichia coli; in DNA synthesis in vitro (R. Wells and R. Inman, eds.). Baltimore: University Park Press 1973 in pressGoogle Scholar