Methyl methacrylate (MMA), a widely used monomer in the manufacture of acrylic polymers, has been reported to cause neurological deficits in industrial workers. The effect of MMA on regional brain biogenic amines and their correlation with behavioural responses were examined. Male Wistar rats received orally MMA (500 mg/kg body wt) for 21 consecutive days. Our results indicate that MMA markedly impaired locomotor activity and learning, while aggressive behaviour significantly increased. An overall enhancement of biogenic amine levels in pons-medulla and hippocampus was noted. In addition, for noradrenaline an increase in cerebral cortex and corpus striatum, for 5-hydroxytryptamine an increase in mid-brain and hypothalamus and for dopamine a slight decrease in corpus striatum were recorded. The changes in regional brain biogenic amine levels may be partly responsible for altered behaviour.
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Anderson K, Fuxe K, Nilsen OG, Toftgard R, Eneroth P, Gustafsson JA (1981) Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, orthometa and paraxylene and ethyl benzene. Toxicol Appl Pharmacol 60: 535–547
Blagodatin VM, Golova IA, Bladokatkina NK, Ramyantseva YP, Goryacheva LA, Aliyeva NK, Gronsberg YS (1976) Establishing the maximum permissible concentration of the methyl ester of methacrylic acid in the air of a work area. Gig Tr Prof Zabol 6: 5–8
Bohling HG, Borchard U, Drouin H (1977) Monomeric methyl-methacrylate acts on desheathed myelinated nerve and on the mode of ranvier. Arch Toxicol 38: 307–317
Chandra SV, Shukla GS, Saxena DK (1979) Manganese-induced behavioural dysfunction and its neurochemical mechanisms in growing mice. J Neurochem 33: 1217–1221
Cook L, Weidley E (1956) Behavioural effects of some psychopharmacological agents. Ann NY Acad Sci 66: 740–752
Crow TJ (1977) Neurotransmitter-related pathways. In: Davison AN (ed) The structure and function of central monoamine neurons. Plenum, NY pp 1–22
Curzon G (1972) Brain amine metabolism in some neurological and psychiatric disorders. In: Cumings JN (ed) Biochemical aspects of nervous diseases. Plenum, London p 151
David AG, Thomas RB, Bridger, WH (1975) The role of catecholamines in animal learning and memory. In: Friedhoff AI (ed) Catecholamines and Behaviour 2 Plenum, NY pp 1–22
Dennis LM, Redmond DE Jr (1975) The catecholamines: Possible role in affect, mood and emotional behaviour. In: Friedhoff AI (ed) Catecholamines and behaviour 2 Plenum, NY pp 73–104
Dixit R, Husain R, Mukhtar H, Seth PK (1981) Effect of acrylamide on biogenic amine levels, monoamine oxidase and cathepsin D activity of rat brain. Environ Res 26: 168–173
Dobrinskij SI (1970) Data concerning problems of industrial hygiene and occupational pathology in the manufacture of acrylic polymers. Gig Tr Prof Zabol 14: 53–54
Fisher RA (1950) Statistical methods for research workers (ed) Oliver & Boyd 11th ed London Oliver & Boyd
Fries I, Fisher AA, Salvati EA (1975) Contact dermatitis in surgeons from methyl methacrylate bone cement. J Bone Joint Surg 57A: 547–549
Glowinski J, Iverson L (1966) Regional studies of catecholamines in the rat brain: I. The disposition of 3H-norepinephrine, 3H-dopamine and 3H-dopa in various regions of the brain. J Neurochem 13: 655–669
Gotter M, Michaelson A (1975) Growth, behaviour and brain catecholamines in lead exposed neonatal rats. Science 187: 359–361
Husain R, Srivastava SP, Mushtaq M, Seth PK (1980) Effect of styrene on levels of serotonin, noradrenaline and dopamine and activity of acetylcholinesterase and monoamine oxidase in rat brain. Toxicol Lett 7: 47–50
Husain R, Zaidi N, Srivastava SP, Seth PK (1985a) Effect of styrene oxide on levels of biogenic amines and activity of monoamine oxidase in different parts of rat brain. Bull Environ Contam Toxicol 34: 712–729
Husain R, Srivastava SP, Seth PK (1985b) Some behavioral effects of early styrene intoxication in experimental animals. Arch Toxicol 57: 53–55
IARC (International Agency for Research on Cancer) (1979) Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol 19 IARC, Lyon, pp 187–212
Innes DL, Tansy MF (1981) Central nervous system effects of methyl methacrylate vapor. Neurotoxicology 2: 515–522
Jacobwitz DM, Richardson JS (1978) Method for the rapid determination of norepinephrine, dopamine and serotonin in the same brain region. Pharmacol Biochem Behav 8: 515–519
Karpov BD (1953) The effect of small concentration of methyl methacrylate vapours on the inhibition and stimulation process of the cortex of the brain. Trud Leningr Sanit Gig Med Inst 14: 43–48
Kuhn WL, VanMaaner (1961) Central nervous system effects of thalidomide. J Pharmacol Exp Ther 134: 60–68
Lloyd KG, Hornykiewiez O (1975) Catecholamines in regulation of motor function. In: Friedhoff AI (ed) Catechoalmines and behaviour 1 Plenum, New York, pp. 41–54
Raines LA (1957) Toxicity of methacrylate in the condition of a dental supplies factory. Gig Tr Prof Zabol 1: 56–57
Tansy MF, Benhayem S, Probst S, Jordan JS (1974) The effects of methyl methacrylate vapor on gastric motor function. JADA 89: 372–376
Tedeschi RE, Tedeschi DH, Mucha A, Cook L, Mattis P, Fellows EJ (1959) Effects of various centrally acting drugs on fighting behavior of mice. J Pharmacol Exp Ther 125: 28–34
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Husain, R., Srivastava, S.P. & Seth, P.K. Methyl methacrylate induced behavioural and neurochemical changes in rats. Arch Toxicol 58, 33–36 (1985). https://doi.org/10.1007/BF00292613
- Biogenic amines
- Methyl methacrylate