To estimate the background fetal loss rates among women who might be candidates for chorionic villi sampling (CVS) for prenatal diagnosis, we examined the frequency of spontaneous abortion and of non-viable fetuses in two groups of women thought to be pregnant at 8–12 weeks' gestation. Among 1519 women over 35 years given an appointment for amniocentesis 1978–1981, 9.8% had a spontaneous abortion prior to 16 weeks' gestation. For those under observation before week 12, the loss rate by 16 weeks was 15.3%. Among all 190 candidates for elective termination of pregnancy between 6 and 12 weeks' gestation, 12.6% were found to have a non-viable fetus at the scheduled date of abortion. The frequency of non-viability was 14% among those seen before week 12. The data suggest that the background loss rate between the time of CVS and the time of amniocentesis is approximately 1–2% and is unlikely to be higher than 9%. Until randomized clinical trials of the procedure are completed we will not know how much, if at all, the loss rate associated with CVS is increased above this background. Nevertheless, knowledge of these background risk estimates may be useful in counseling women considering participating in trials of CVS.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bryce RL, Fuller PJ, Mohide PT, Tomkins D, Davidson RG, Feeny D, Torrance G (1984) Clinical trial of chorion biopsy. Can Med Assoc J 130:1109
French FE, Bierman JM (1962) Probabilities of fetal mortality. Public Health Rep 77:835–847
Gustavii B (1984) Chorionic biopsy and miscarriage in first trimester. Lancet 1:562
Hecht F, Hecht BK, Bixenman HA (1984) Caution about chorionic villi sampling in the first trimester. N Engl J Med 310:1388
Hobbins JC (1983) Determination of fetal sex in early pregnancy. N Engl J Med 309:979–980
Jackson LG, Wapner RJ (to be published) Risks of chorionic biopsy
Lippman A (1984) Consequences of chorionic biopsy. N Engl J Med 310:1121
Perry TB, Vekemans MJJ, Lippman A, Hamilton EF, Fournier PJR (to be published) Chorionic villus sampling: clinical experience, immediate complications and patient attitudes. Am J Obstet Gynecol (in press) (1985)
About this article
Cite this article
Lippman, A., Vekemans, M.J.J. & Perry, T.B. Fetal mortality at the time of chorionic villi sampling. Hum Genet 68, 337–339 (1984). https://doi.org/10.1007/BF00292596
- Clinical Trial
- Internal Medicine
- Metabolic Disease
- Loss Rate
- Risk Estimate