Cytogenetic analyses were carried out in lymphocytes of 37 persons before and during a primary chemoprophylaxis or a preventive chemotherapy with isoniazid as weil as of 30 patients suffering from active pulmonary tuberculosis before and during a chemotherapy with isoniazid in combination with two other antimycobacterial drugs. The results of the four participating research groups consistently reveal no indication for a chromosome damaging activity of isoniazid, of its metabolites in the human organism and of the administered drug regimens.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Braun, R., Schubert, J., Schöneich, J.: On the mutagenicity of isoniazid. Biol. Zbl. 94, 423–436 (1976)
Cirnu-Georgian, L., Lenghel, V.: Isoniazid-induced chromosome aberrations. Lancet 1971II, 93
Dudin, G., Beek, B., Obe, G.: The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutation Res. 23, 279–281 (1974)
Gebhart, E.: Chromosomenuntersuchungen bei Bactrim®-Therapie. Med. Klin. 68, 878–881 (1973)
Gebhart, E., Schwanitz, G., Hartwich, G.: The dose-effect problem in cytogenetic studies in vivo in chemotherapeutically treated probands. 4th Ann. Meet. EEMS, Heidelberg 1974
Lüers, H., Obe, G.: Action of isoniazid on human chromosomes in vitro. EMS Newsletter No. 4, 36 (1971)
Lubs, H. A., Samuelson, J.: Chromosome abnormalities in lymphocytes from normal human subjects. Cytogenetics 6, 402–411 (1967)
Meist, H.: Strukturelle Chromosomenaberrationen in den Lymphocyten gesunder Probanden unter dem Einfluß verschiedener Kulturbedingungen. Acta Genet. Med. Gemellol. 20, 174–188 (1971)
Obe, G., Beek, B., Radenbach, K. L.: Action of antituberculosis drugs on human leukocyte chromosomes in vitro. Experientia 29, 1433–1434 (1973)
Röhrborn, G., Propping, P., Buselmaier, W.: Mutagenic activity of isoniazid and hydrazine in mammalian test systems. Mutation Res. 16, 189–194 (1972)
Vogel, E., Obe, G.: Testing of rifampicin on possible genetic effects on Drosophila melanogaster and human leukocyte chromosomes in vitro. Experientia 29, 124–125 (1973)
Weber, E.: Grundriß der biologischen Statistik. Stuttgart: G. Fischer 1967
About this article
Cite this article
Bauchinger, M., Gebhart, E., Fonatsch, C. et al. Chromosome analyses in man in the course of chemoprophylaxis against tuberculosis and of antituberculosis chemotherapy with isoniazid. Hum Genet 42, 31–43 (1978). https://doi.org/10.1007/BF00291621
- Internal Medicine
- Research Group
- Metabolic Disease