Two extra bisatellited chromosome identified as inv dup (15) (pter→q11.2::q11.2→pter) were found in an oligoasthenospermic male. Analysis of Ag-staining in the proband and in one fertile brother with a normal karyotype revealed that nucleolar organizer region (NOR) activity was significantly increased in the patient. The frequency of satellite associations was also significantly higher in the index case, but no correlation was found between NOR activity and acrocentric associations. These results suggest that extra NOR activity and the elevated frequency of satellite associations could predispose to gametogenic impairment.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Chandley AC, Edmon P, Christie S, Gowans L, Fletcher J, Frackiewicz A, Newton M (1975) Cytogenetics and infertility in man. I. Karyotype and seminal analysis. Ann Hum Genet 39:231–253
De Capoa A, Ferraro M, Menendez F, Mostacci C, Pelliccia F, Rocchi A (1978) Ag-staining of the nucleolar organizer (NO) and its relationship to satellite association. Hum Genet 44:71–77
De Gutierrez AC, Salamanca F, Lisker R, Segovia A (1975) Supernumerary bisatellited chromosome in a family ascertained through a patient with Sturge-Weber syndrome. Ann Génét (Paris) 18:45–49
Galperin-Lemaitre H, Hens L, Séle B (1980) Comparison of acrocentric associations in male and female cells. Relationship to the active nucleolar organizers. Hum Genet 54:349–353
Miller DA, Tantravahi R, Dev VG, Miller OJ (1977) Frequency of satellite association of human chromosomes is correlated with amount of Ag-staining of the nucleolar organizer region. Am J Hum Genet 29:490–502
Pérez-Castillo A, Martín-Lucas MA, Abrisqueta JA (1986) New insights into the effects of extra nucleolus organizer regions. Hum Genet 72:80–82
Rosenmann A, Wahrman J, Richler C, Voss R, Persitz A, Goldman B (1985) Meiotic association between the XY chromosomes and unpaired autosomal elements as a cause of human male sterility. Cytogenet Cell Genet 39:19–29
Schreck RR, Breg WE, Erlanger BF, Miller OJ (1977) Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15. Hum Genet 36:1–12
Sergovich FR, Luce A, Carr D (1967) Chromosome aneuploidy in the father of a mongol. Am J Dis Child 114:407
Sigmund J, Schwarzacher HG, Mikelsaar AV (1979) Satellite association frequency and number of nucleoli depend on cell cycle duration and NOR-activity. Hum Genet 50:81–91
Soudek D, McCreary BD, Laraya P, Dill FJ (1973) Two kinships with accessory bisatellited chromosomes. Ann Génét (Paris) 2:101–107
Sozansky OA, Zakharov AF, Terekhov SM (1985) Intercellular NOR-Ag-variability in man. II. Search for determining factors, clonal analysis. Hum Genet 69:151–156
Steinbach P, Djalali M, Hansmann I, Kattner E, Meisel-Stosiek M, Probeck HD, Schmidt A, Wolf M (1983) The genetic significance of accessory bisatellited marker chromosomes. Hum Genet 65: 155–164
Van Dyke DL, Weiss L, Logan M, Pai GS (1977) The origin and behavior of two isodicentric bisatellited chromosomes. Am J Hum Genet 29:294–300
Walzer S, Gerald PS (1972) Chromosome abnormalities in 11154 newborn infants. Am J Hum Genet 24:38a
Wisniewski LP, Doherty RA (1985) Supernumerary microchromosomes identified as inverted duplications of chromosome 15: a report of three cases. Hum Genet 69:161–163
Wisniewski L, Hassold T, Heffelfinger J, Higgins JV (1979) Cytogenetic and clinical studies in five cases of inv dup (15). Hum Genet 50:259–270
Zakharov AF, Davudov AZ, Benjush VA, Egolina NA (1982) Genetic determination of NOR activity in human lymphocytes from twins. Hum Genet 60:24–29
About this article
Cite this article
Martín-Lucas, M.A., Pérez-Castillo, A. & Abrisqueta, J.A. Infertility associated with two accessory bisatellited chromosomes. Hum Genet 73, 133–136 (1986). https://doi.org/10.1007/BF00291603
- Internal Medicine
- Metabolic Disease
- Index Case
- Organizer Region