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Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin

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Summary

In lymphocyte cultures of nine children suffering from epilepsy and therefore treated with phenytoin (DPH), increased sister chromatid exchanges (SCE) were found. Their average SCE-rate exceeded that of a normal control group by 55%.

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References

  1. Esser KJ, Kotlarek F, Habedank M, Mühler U, Mühler E (1981) Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone. Hum Genet 56:345–348

  2. Gebhart E (1981) Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing. Hum Genet 58: 235–254

  3. Hunke MH, Carpenter NJ (1978) Effects of diphenylhydantoin on the frequency of sister chromatid exchanges in human lymphocytes. Am J Hum Genet 30:1 (Abstract 83A)

  4. Korenberg JR, Freedlander EF (1974) Giemsa technique for detecting of sister chromatid exchanges. Chromosoma 48:335–360

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Author information

Correspondence to M. Habedank.

Additional information

This work contains parts of the M.D. thesis of C. Stumpf

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Habedank, M., Eßer, K.-., Brüll, D. et al. Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin. Hum Genet 61, 71–72 (1982). https://doi.org/10.1007/BF00291338

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Keywords

  • Internal Medicine
  • Normal Control
  • Metabolic Disease
  • Sister Chromatid
  • Normal Control Group