An analysis of labelled centromere regions of chromosomes in metaphase cells of the Swamp Wallaby (Wallabia bicolor) demonstrates conclusively that chromatids do not co-segregate in sets which contain DNA template strands of identical age. Also, there is no tendency for chromatids of homologous chromosome pairs to distribute non-randomly. The data are consistent with the assumption of random distribution of chromatids at mitosis.
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Comings, D. E.: The distribution of sister chromatids at mitosis in Chinese hamster cells. Chromosoma (Berl.) 39, 428–433 (1970)
Cuevas-Sosa, A.: Human chromosomology: segregation of chromatids in diploid cells in vitro. Nature (Lond.) 218, 1059–1061 (1968)
Eberle, H., Lark, K. E.: Chromosome segregation in Bacillus subtilis. J. molec. Biol. 22, 183–186 (1966)
Feinendegen, L. E.: Tritium-labeled molecules in biology and medicine. New York: Academic Press 1967
Geard, C. R.: Studies in chromosome structure and replication. M. Sc. Thesis, University of Tasmania, Hobart 1969
Gibson, D. A., Prescott, D. M.: Induction of sister chromatid exchanges in chromosomes of rat kangaroo cells by tritium incorporated into DNA. Exp. Cell Res. 74, 397–402 (1972)
Heddle, J. A., Wolff, S., Whissell, D., Cleaver, J.: Distribution of chromatids at mitosis. Science 158, 929–931 (1967)
Jacob, F., Ryter, A., Cuzin, F.: On the association between DNA and membrane in bacteria. Proc. roy. Soc. London, B 164, 267–278 (1966)
Lark, K. G.: Regulation of chromosome replication and segregation in bacteria. Bact. Rev. 30, 3–32 (1966)
Lark, K. G.: Nonrandom segregation of sister chromatids in Vicia f aba and Triticum boeoticum. Proc. nat. Acad. Sci. (Wash.) 58, 352–359 (1967)
Lark, K. G.: Sister chromatid segregation during mitosis in polyploid wheat. Genetics 62, 289–305 (1969a)
Lark, K. G.: Nonrandom segregation of sister chromatids. In: Genetics and developmental biology (H. Teas, ed.), p. 8–24. Lexington: University of Kentucky Press 1969 (b)
Lark, K. G., Bird, R. E.: Segregation of the conserved units of DNA in Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 54, 1444–1450 (1965)
Lark, K. G., Consigla, R. A., Minocha, H. C.: Segregation of sister chromatids in mammalian cells. Science 154, 1202–1205 (1966)
Marin, G., Prescott, D. M.: The frequency of sister chromatid exchanges following exposure to varying doses of 3H-thymidine or X-rays. J. Cell Biol. 21, 159–167 (1964)
Nicklas, R. B.: Mitosis. Advanc. Cell Biol. 2, 225–298 (1971)
Priest, J. H., Shikes, R. H.: Distribution of labelled chromatin. I. M1 and M2 anaphases of diploid and tetraploid cultured mammalian cells. J. Cell Biol. 47, 99–106 (1970)
Rosenberger, R. F., Kessel, M.: Non-random sister chromatid segregation and nuclear migration in hyphae of Aspergillus nidulans. J. Bact. 96, 1208–1218 (1968)
Wolff, S., Heddle, J. A.: Some chromosome studies with tritiated thymidine. In: Replication and recombination of genetic material (Peacock and Brock, eds.) p. 105–113. Canberra: Australian Academy of Science 1968
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Geard, C.R. Chromatid distribution at mitosis in cultured Wallabia bicolor cells. Chromosoma 44, 301–308 (1973). https://doi.org/10.1007/BF00291024
- Developmental Biology
- Random Distribution
- Chromosome Pair
- Homologous Chromosome
- Centromere Region