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The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome


Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizacus-Merzbacher disease in man.

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Correspondence to P. Jollès.

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Mattei, M.G., Alliel, P.M., Dautigny, A. et al. The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome. Hum Genet 72, 352–353 (1986).

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  • Internal Medicine
  • Metabolic Disease
  • Recombinant Plasmid
  • Demyelination Disease
  • Plasmid Clone