Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizacus-Merzbacher disease in man.
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Mattei, M.G., Alliel, P.M., Dautigny, A. et al. The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome. Hum Genet 72, 352–353 (1986). https://doi.org/10.1007/BF00290964
- Internal Medicine
- Metabolic Disease
- Recombinant Plasmid
- Demyelination Disease
- Plasmid Clone