A cytogenetic follow-up has been made of nine mixoploid children found among 11 148 consecutive newborn children.
The frequency of the cell line with normal chromosomes increased in all but two, and the increase was statistically significant, being from 20% to 39% in four cases, and from 1% to 17% in three, while in one case there was no difference from the first to the last examination. The possibility that children with mixoploid chromosome abnormalities at birth will reveal no cell line with a chromosome abnormality in lymphocyte cultures as adults, despite having clinical signs of the chromosome aberration found in one cell line at birth is discussed, as is the question of cell selection in vivo.
The mixoploid children had fewer clinical symptoms and fewer signs of the chromosome abnormalities found in some of their cells than children with the same chromosome abnormalities in all cells.
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Bochkov NP, Kuleshov NP, Chebotarev AN, Alekhin VI, Midian SA (1974) Population cytogenetic investigation of newborns in Moscow. Hum Genet 22:139–152
Ford CE (1967) Foundation Study Group No. 25 in Mongolism. Churchill, London (Ciba publication no. 71)
Friedrich U, Nielsen J (1973) Chromosome studies in 5,049 consecutive newborn children. Clin Genet 4:333–343
Hook EB (1977) Exclusion of chromosomal mosaicism: Tables of 90%, 95%, and 99% confidence limits and comments on use. J Hum Genet 29:94–97
Nielsen J (1976) Cell selection in vivo in normal/aneuploid chromosome abnormalities. Hum Genet 32:203–206
Nielsen J, Sillesen I (1975) Incidence of chromosome aberrations among 11,148 newborn children. Hum Genet 30:1–12
Nielsen J, Sillesen I, Sørensen AM, Sørensen K (1979) Follow-up until age 4 to 8 of 25 unselected children with sex chromosome abnormalities, compared with sibs and controls. In: Robinson A, Lubs HA, Bergsma D (eds) Sex chromosome aneuploidy: Prospective studies on children. Birth Defects 15:1
Taylor AI (1968) Cell selection in vivo in normal/G trisomic mosaics. Nature 219:1028–1030
Taylor AI (1970) Further observation of cell selection in vivo in normal/G trisomic mosaics. Nature 227:163–164
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Nielsen, J., Krag-Olsen, B. Cell selection in vivo. Hum Genet 55, 357–361 (1980). https://doi.org/10.1007/BF00290218
- Internal Medicine
- Clinical Sign
- Clinical Symptom
- Cell Selection
- Metabolic Disease