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Chromosomes in acute leukemia

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Summary

The karyotype of leukemic cells of 78 acute leukemia patients (37 ANLL, 34ALL, and 7 of unknown type) was studied by means of G-banding. Chromsomal abnormalities were found in 50 patients (72%). Chromosomes 8, 21, 5, 7, 11, and 19 were preferentially involeved in the abnormalities, both in ANLL and in ALL. A high incidence of the characteristic rearrangement t(8,21) was noted in AML: (in 6 of 22 AML patients). An identical reciprocal translocation—t(4;11)—was seen in 4 out of 34 ALL patients.

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Correspondence to E. L. Prigogina.

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Prigogina, E.L., Fleischman, E.W., Puchkova, G.P. et al. Chromosomes in acute leukemia. Hum Genet 53, 5–16 (1979). https://doi.org/10.1007/BF00289443

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Keywords

  • Internal Medicine
  • Leukemia
  • Metabolic Disease
  • Leukemic Cell
  • Acute Leukemia