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Tissue variability of the phosphotransferases adenylate kinase (EC: 2.7.4.3.) and pyruvate kinase (EC: 2.7.1.40.)

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Summary

Studies of the tissue variability of human AK and PK are reported. Homozygous probands of phenotype AK 1, show five electrophoretic positions with AK activity in different tissues and six positions with PK activity. In one of the 20 probands studied the brain, not however any other tissue, revealed a different zymogram. It can be followed therefore that different isozymes can be present in different tissues.

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References

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Head: Prof. Dr. Dr. H. Baitsch

Supported by the Deutsche Forschungsgemeinschaft.

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Böckelmann, W., Ritter, H. Tissue variability of the phosphotransferases adenylate kinase (EC: 2.7.4.3.) and pyruvate kinase (EC: 2.7.1.40.). Hum Genet 6, 373–376 (1968). https://doi.org/10.1007/BF00286808

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Keywords

  • Internal Medicine
  • Pyruvate
  • Metabolic Disease
  • Pyruvate Kinase
  • Adenylate Kinase