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Strain difference in mercury excretion in methylmercury-treated mice

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Abstract

The strain differences in mercury excretion and organ distribution after administration of methylmercuric chloride (5 mg/kg) were studied in male mice of four strains, C57BL/6N, BALB/cA, C3H/HeN and AKR. The urinary excretion rate of mercury for 5 days following administration was 3.9–4.7 times higher in the C57BL strain than in the other three strains, whereas the mercury level in feces was highest in the AKR strain. Although the blood mercury concentration in the C57BL strain was almost half that in the others up to the 5th day, the plasma levels did not vary so widely. C57BL showed the highest ratio of plasma to whole blood mercury level, which was thought to originate from the lower affinity of methylmercury for hemoglobin. The variation of the plasma/whole blood ratios was rather small throughout the experimental period in each strain examined. In the C57BL strain, the mercury levels in brain, liver, kidney and blood were significantly lower on and after the 5th day than in the other three strains, probably because of the rapid elimination of body mercury into urine, but the mercury uptake by the brain and kidney 5 min after administration was at a rather higher rate than in the other strains. On the other hand, the highest tissue levels were shown by the C3H strain in the brain and liver, and by the BALB/c strain in the kidney. It was suggested that in the C57BL strain, the higher mercury distribution in plasma and rapid uptake by the kidney might result in higher urinary excretion.

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References

  1. Al-Shahristani H, Shihab KM (1974) Variation of biological half-life of methylmercury in man. Arch Environ Health 19: 478–484

  2. Ballatori N, Clarkson TW (1982) Developmental changes in the biliary excretion of methylmercury and glutathione. Science 216: 61–63

  3. Clarkson TW (1972) Recent advances in the toxicology of mercury with emphasis on the alkylmercurials. CRC Crit Rev Toxicol 1: 203–234

  4. Dayhoff MO, Hunt LT, McLaughlin PJ, Barker WC (1972) Globins. In: Dayhoff MO (ed) Atlas of protein sequence and structure. National Biomedical Research Foundation, Washington, D. C., vol 5. D 51–85

  5. Doi R, Kobayashi T (1982) Organ distribution and biological half-time of methylmercury in four strains of mice. Jpn J Exp Med 52: 307–314

  6. Doi R, Tagawa M, Tanaka H, Nakaya K (1983) Hereditary analysis of the strain difference of methylmercury distribution in mice. Toxicol Appl Pharmacol 69: 400–406

  7. Evans HL, Garman RH, Weiss B (1977) Methylmercury: Exposure duration and regional distribution as determinants of neurotoxicity in nonhuman primates. Toxicol Appl Pharmacol 41: 15–33

  8. Hunt LT, Dayhoff MO (1976) Globins. In: Dayhoff MO (ed) Atlas of protein sequence and structure. National Biomedical Research Foundation, Washington, D. C., vol. 5, Suppl. 2, pp 191–223

  9. Iverson F, Downie RH, Paul C, Trenholm HL (1973) Methylmercury: Acute toxicity, tissue distribution and decay profiles in the guinea pig. Toxicol Appl Pharmacol 24: 545–554

  10. Jacobs MB, Yamaguchi S, Goldwater LJ, Gilbert H (1960) Determination of mercury in blood. Am Ind Hyg Assoc J 21: 475–480

  11. Kostyniak PJ (1980) Differences in elimination rates of methylmercury between two genetic variant strains of mice. Toxicol Lett 6: 405–410

  12. Miettinen JK, Rahola T, Hattula T, Rissanen K, Tillander M (1971) Elimination of 203Hg-methylmercury in man. Ann Clin Res 3: 116–122

  13. Nordberg GN, Skerfving S (1972) Metabolism. In: Friberg L, Vostal D (eds) Mercury in the environment. CRC Press, Cleveland, Ohio, pp 29–90

  14. Rowland IR, Robinson RD, Doherty RA (1984) Effects of diet on mercury metabolism and excretion in mice given methylmercury: Role of gut flora. Arch Environ Health 39: 401–408

  15. Simpson RB (1961) Association constants of methylmercury with sulfhydryl and other bases: J Am Chem Soc 83: 4711–4717

  16. Swensson A, Ulfvarson U (1968) Distribution and excretion of mercury compounds in rats over a long period after a single injection. Acta Pharmacol Toxicol 26: 273–283

  17. Tagashira E, Urano T, Yanaura S (1980) Methylmercury toxicosis. I. Relationship between the onset of motor incoordination and mercury contents in the brain. Folia Pharmacol Japon 76: 169–177

  18. Takeuchi T, Eto K (1974) Pathogenesis of chronic Minamata disease (chronic methylmercury poisoning). Adv Neurol Sci 18: 845–860

  19. Tsubaki T (1968) Organic mercury intoxication in the Agano River area studied by Niigata University Research Group. Clin Neurol 8: 511–520

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Correspondence to Akira Yasutake.

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Yasutake, A., Hirayama, K. Strain difference in mercury excretion in methylmercury-treated mice. Arch Toxicol 59, 99–102 (1986). https://doi.org/10.1007/BF00286731

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Key words

  • Methylmercury
  • Excretion
  • Distribution
  • Strain difference
  • Mouse