Two human ring chromosomes 18 were isolated intact in a Langmuir trough, critical-point dried, and studied by quantitative electron microscopy. The portion of deleted genetic material is calculated from dry-mass determinations and is found to be comparable to the total genetic material present in the bacterium Salmonella typhimurium.
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Preliminary presentation of this study was made (Golomb and Bahr, 1971a).
This study has been supported by American Cancer Society Grant No. P259-j.
The opinions or assertions contained herein are the private views of authors and are not to be construed as official or as reflecting the views of the department of the Army or the Department of Defense.
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Grolomb, H.M., Bahr, G.F. & Borgaonkar, D.S. Analysis of human chromosomal variants by quantitative electron microscopy. Chromosoma 34, 94–98 (1971). https://doi.org/10.1007/BF00285519
- Electron Microscopy
- Developmental Biology
- Genetic Material
- Ring Chromosome
- Chromosomal Variant