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Impairment of capping in lymphoblastoid cell lines of Duchenne patients indicates an intrinsic cellular defect

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Duchenne muscular dystrophy (DMD) is a lethal sex-linked degenerative disorder of the muscle in man. Generalized cell membrane abnormalities seem to be involved in the pathogenesis of the disease; in particular, the impairment of lymphocyte capping capacities has been repeatedly confimed. To clarify whether capping impairment is a consequence of factors related to the activity of the disease or an expression of an intrinsic cellular defect, we have investigated the capping capacities of DMD EBV-transformed cell lines. The results indicate a significant impairment of capping capacity in cultured cell lines, providing evidence for an intrinsic cell deficiency in DMD.

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Correspondence to O. R. Baricordi.

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Baricordi, O.R., Sensi, A., Balboni, A. et al. Impairment of capping in lymphoblastoid cell lines of Duchenne patients indicates an intrinsic cellular defect. Hum Genet 83, 217–219 (1989). https://doi.org/10.1007/BF00285158

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  • Cell Membrane
  • Internal Medicine
  • Metabolic Disease
  • Muscular Dystrophy
  • Generalize Cell