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Chromosomal aberrations in heavy smokers

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Lymphocyte chromosomes from 20 heavy smokers were analyzed from 48-h whole blood cultures for the frequency of dicentric chromosomes, ring chromosomes, and chromatid translocations. Compared to controls, these exchange type aberrations occurred more frequently in the smokers.

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  1. Anonymous: Are 90% of cancers preventable? Lancet 1977I, 685–687

  2. Benedict, W. F., Rucker, N., Faust, J., Kouri, R. E.: Maliganant transformation of mouse cells by cigarette smoke condensate. Cancer Res. 35, 857–860 (1975)

  3. Doll, R., Peto, R.: Mortality in relation to smoking: 20 years' observations on male British doctors. Brit. Med. J. 2, 1525–1536 (1976)

  4. Dudin, G., Beek, B., Obe, G.: The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutation Res. 23, 279–281 (1974)

  5. Freeman, A. E., Kelloff, G. J., Gilden, R. V., Lane, W. T., Swain, A. P., Huebner, R. J.: Activation and isolation of hamster-specific C-type viruses from tumors induced by cell cultures transformed by chemical carcinogens. Proc. Natl. Acad. Sci. USA 68, 2386–2390 (1971)

  6. Gori, G. B.: Low-risk cigarettes: A prescription. Science 194, 1243–1246 (1976)

  7. Herha, J., Obe, G.: Chromosomal damage in chronical users of Cannabis. In vivo investigation with two-day leukocyte cultures. Pharmacopyschiat. 7, 328–337 (1974)

  8. Herha, J., Obe, G.: Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin. Hum. Genet. 34, 255–263 (1976)

  9. Herha, J., Obe, G.: Chromosomal damage in patients with epilepsy: Possible mutagenic properties of long-term antiepileptic drug treatment. In: Epilepsy, the eighth international symposium, J. K. Penry, ed., pp. 87–94. New York: Raven Press 1977

  10. Hoffmann, D., Wynder, E. L.: Smoking and occupational cancers. Prev. Med. 5, 245–261 (1976)

  11. Hutton, J. J., Hackney, C.: Metabolism of cigarette smoke condensates by human and rat homogenates to form mutagens detectable by Salmonella typhimurium TA 1538. Cancer Res. 35, 2461–2468 (1975)

  12. Kier, L. D., Yamasaki, E., Ames, B. N.: Detection of mutagenic activity in cigarette smoke condensates. Proc. Natl. Acad. Sci. USA 71, 4159–4163 (1974)

  13. Lasnitzki, I.: The effect of a hydrocarbon-enriched fraction of cigarette smoke condensate on human fetal lung grown in vitro. Cancer Res. 28, 510–516 (1968)

  14. Mizusaki, S., Takashima, T., Tomaru, K.: Factor affecting mutagenic activity of cigarette smoke condensate in Salmonella typhimurium TA 1538. Mutation Res. 48, 29–36 (1977)

  15. Obe, G., Ristow, H.: Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster cells in vitro. Mutation Res. 56, 211–213 (1977)

  16. Obe, G., Ristow, H., Herha, J.: Chromosomal damage by alcohol in vitro and in vivo. In: Alcohol intoxication and withdrawal-IIIa. Biological aspects of ethanol. Advances in experimental medicine and biology, Vol. 85A, M. M. Gross, ed., pp. 47–70. New York: Plenum Press 1977a

  17. Obe, G., Ristow, H., Herha, J.: The effect of alcohol on chromosomal structure and function. In: Pharmacology of ethanol, E. Majchrowizc, E. P. Noble, eds. New York: Plenum Press (in preparation, 1977b)

  18. Ristow, H., Obe, G.: Acetadehyde induces cross-links in DNA and causes sister chromatid exchanges in human cells. Mutation Res. (in press, 1978)

  19. World Health Organization Expert Committee: Smoking and its effects on health. W.H.O. Tech. Rep. Ser., No. 568 (1975)

  20. Wynder, E. L., Hoffmann, D.: Experimental tobacco carcinogenesis. Science 162, 862–871 (1968)

  21. Yamasaki, E., Ames, B. N.: Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine. Proc. Natl. Acad. Sci. USA 74, 3555–3559 (1977)

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Obe, G., Herha, J. Chromosomal aberrations in heavy smokers. Hum Genet 41, 259–263 (1978).

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  • Internal Medicine
  • Metabolic Disease
  • Blood Culture
  • Chromosomal Aberration
  • Heavy Smoker