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Hepatitis B virus, cirrhosis and primary carcinoma of the liver

An electron microscopic study

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Summary

The core and coat of hepatitis B virus were found by electron microscopy in parenchymal cells of a liver biopsy from a 61 year old man with chronic active hepatitis and cirrhosis of the liver. Laparoscopy, 35 days after liver biopsy, and autopsy 42 days later confirmed the cirrhosis and showed in addition a well differentiated hepatoma. The possibility of a viral aetiology for the cirrhosis and primary carcinoma of the liver is considered.

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References

  1. Alpert,E., Isselbacher,K.J.: Hepatitis associated antigen and hepatoma in the U.S. Lancet 1971/2, 1087

  2. Bartók,I., Decastello,A.: Hepatitis B antigen in liver cirrhosis and hepatocellular carcinoma. Acta Hepatogastroenterol. 22, 379–386 (1975)

  3. Campion,E.C, Ludbrook,J., McLeod,J.M, Marshall,V.R., Mukherjee,T., Wangel,A.G.: Primary hepatoma and hepatitis-associated antigen in young white woman. Brit. med. J. 4, 149–150 (1972)

  4. Chainuvati,T., Viranuvati,V., Pongpipat,D.: Relationship of hepatitis B antigen and hepatoma in Thailand. Gastroenterology 68, 1261–1264 (1975)

  5. Dourdourekas,D., Villa,F., Szanto,P.B., Steigmann,F.: Hepatocellular carcinoma; relation to alcohol, HB-antigen and alpha-feto-protein. Amer. J. Gastroenterology 63, 307–311 (1975)

  6. Farber,E.: Environmental factors in the development of liver cancer. In: The liver and its diseases (eds.: F. Schaffner, S. Sherlock, C.M. Leevy), pp. 337–341. New York: Intercontinental Medical Book Corporation 1974

  7. Gibson,J.B.: Parasites, liver disease and liver cancer. Liver Cancer-International Agency for Research on Cancer Scientific Publications No 1. pp. 42–50, 1971

  8. Gudat,F., Bianchi,L., Sonnabend,W., Thiel,G., Aenishaenslin,W., Stalder,G.A.: Pattern of core and surface expression in liver tissue reflects state of specific immune response in hepatitis B. Lab. Invest. 32, 1–9 (1975)

  9. Hadziyannis,S., Gerber,M.A., Vissoulis,C., Popper,H.: Cytoplasmic hepatitis B antigen in “ground-glass” hepatocytes of carriers. Arch. Path. 96, 327–330 (1973)

  10. Huang,S.N.: Hepatitis-associated antigen hepatitis. An electron microscopic study of virus-like particles in liver cells. Amer. J. Path. 64, 483–500 (1971)

  11. Kendrey,G.: Die Rolle der Virushepatitis bei der Entstehung des primären Leberkrebses. Beitr. path. Anat. 120, 1–12 (1959)

  12. Kendrey,G., Szalka,A., László,B., Binder,L., Hollós,I.: Immunosuppressive therapy and virus cores in HBs-Ag-positive chronic hepatitis. Klin. Wschr. 53, 1081–1082 (1975)

  13. Krawczynski,K., Nazarevicz,T., Brzosko,W.J., Nowoslawski,A.: Cellular localisation of hepatitis associated antigen in livers of patients with different forms of hepatitis. J. Infect. Dis 126, 373–377 (1972)

  14. Magee,P.N.: Liver carcinogens in the human environment. Liver Cancer-International Agency for Research on Cancer Scientific Publications. No 1. pp. 110–120 (1971)

  15. Schaff,Zs., Lapis,K., Sáfrány,L.: The ultrastructure of primary hepatocellular cancer in man. Virchows Arch. Abt. A.. Path. Anat. 352, 340–358 (1971)

  16. Sherlock,S., Fox,R.A., Niazi,P.J., Scheuer,P.J.: Chronic liver disease and primary liver-cell cancer with hepatitis-associated (Australia) antigen in serum. Lancet 1970/1, 1243–1247

  17. Tannenbaum,A., Silverstone,H.: Nutrition in relation to cancer. Advan. Cancer Res. 1, 451–501 (1953)

  18. Vogel,C.L., Anthony,P.P., Sadikali,F., Barker,L.F., Peterson,M.R.: Hepatitis associated antigen and antibody in hepatocellular carcinoma: results of a continuing study. J. nat. Cancer Inst. 48, 1583–1588 (1972)

Reference

  1. Blumberg,B.S., Larouzé,B., London,W.T., Werner,B., Hesser,J.A., Millman,I., Saimot,G., Payet,M.: The relation of infection with hepatitis B agent to primary hepatic carcinoma. Amer. J. Path. 81, 669–682 (1975)

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Kendrey, G., László, B. Hepatitis B virus, cirrhosis and primary carcinoma of the liver. Z. Krebsforsch. 88, 97–100 (1976). https://doi.org/10.1007/BF00284749

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Keywords

  • Public Health
  • Carcinoma
  • Electron Microscopy
  • Hepatitis
  • Cancer Research