A continuous increase in the incidence of Down syndrome in Sweden was noted during 1979–1981. This increase mainly occurred among children of younger mothers and was more pronounced for hte males than for the females. There was no evidence of a significant seasonal variation, increased frequency of prematurely born children, or decrease in the number of cases aborted after prenatal diagnosis. An analysis of the whole 15-year period indicates that the incidence of Down syndrome has increased slowly in both sexes, and that there might have been a superimposed cyclic variation limited to the males.
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Iselius, L., Lindsten, J. Changes in the incidence of Down syndrome in Sweden during 1968–1982. Hum Genet 72, 133–139 (1986). https://doi.org/10.1007/BF00283931
- Internal Medicine
- Seasonal Variation
- Metabolic Disease
- Down Syndrome
- Prenatal Diagnosis