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Racial differences in alcohol sensitivity: A new hypothesis

Summary

A hypothesis regarding alcohol sensitivity in Japanese due to a polymorphism of liver aldehyde dehydrogenase (ALDH) is presented. ALDH was found to show two major bands, a faster migrating isozyme with a low Km for acetaldehyde and a slower migrating isozyme with a high Km for acetaldehyde. Out of 40 livers of Japanese, 21 had only the slower migrating isozyme. No such variation was detected in 68 autopsy livers of Germans. Our data suggest that the initial alcohol sensitivity, quite common in individuals of Mongoloid origin, might be due to a delayed oxidation of acetaldehyde rather than its higher than normal production by atypical alcohol dehydrogenase.

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References

  1. Asmussen, E., Hald, J., Larsen, V.: The pharmacological action of acetaldehyde on the human organism. Acta Pharmacol. Toxicol. (Kbh.) 4, 311–320 (1948)

  2. Edwards, J. A., Evans, D. A. P.: Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase. Clin. Pharmacol. Ther. 8, 824–829 (1967)

  3. Ewing, J. A., Rouse, B. A., Pellizzari, E. D.: Alcohol sensibility and ethnic background. Am. J. Psychiatry 131, 206–210 (1974)

  4. Greenfield, N. J., Pietruszko, R.: Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Biochim. Biophys. Acta 483, 35–45 (1977)

  5. Goedde, H. W., Agarwal, D. P., Harada, S.: Alcohol metabolizing enzymes: studies of isozymes in human biopsies and cultured fibroblasts. Clin. Genet. 16, 29–33 (1979)

  6. Goedde, H. W., Agarwal, D. P., Harada, S.: Genetic studies on ADH and ALDH: detection of normal and variant forms in human hair roots. Communicated (1980)

  7. Harada, S., Agarwal, D. P., Goedde, H. W.: Human liver alcohol dehydrogenase isozyme variation: Improved separation methods using prolonged high voltage starch gel electrophoresis and isoelectric focusing. Hum. Genet. 40, 215–220 (1978a)

  8. Harada, S., Agarwal, D. P., Goedde, H. W.: Isozyme variations in acetaldehyde dehydrogenase (E.C. 1.2.1.3.) in human tissues. Hum. Genet. 44, 181–185 (1978b)

  9. Harada, S., Misawa, S., Agarwal, D. P., Goedde, H. W.: Studies on liver alcohol and acetaldehyde dehydrogenase variants in Japanese. Hoppe-Seylers Z. Physiol. Chem. 360, 278 (1979)

  10. Korsten, M. A., Matsuzaki, S., Feinman, L., Lieber, C. S.: High blood acetaldehyde levels after ethanol administration. N. Engl. J. Med. 292, 386–389 (1975)

  11. Lindros, K. O.: Regulatory factors in hepatic acetaldehyde metabolism during ethanol oxidation. Finnish Foundation for Alcohol Studies 23, 67–81 (1975)

  12. Mizoi, Y., Ijiri, I., Tatsuno, Y., Kijima, T., Fujiwara, S., Adachi, J., Hishida, S.: Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol. Biochem. Behavior 10, 303–311 (1979)

  13. Raskin, N. H.: Alcoholism or acetaldehydism? N. Engl. J. Med. 292, 422–423 (1975)

  14. Reed, T. E., Kalant, H., Gibbins, R. T., Kapur, B. M., Rankin, J. G.: Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds. Can. Med. Assoc. J. 115, 851–855 (1976)

  15. Reed, T. E.: Racial comparisons of alcohol metabolism: Background, problems and results. Alcoholism: Clin. Exp. Res. 2, 83–87 (1978)

  16. Schuckit, M. A., Rayses, V.: Ethanolingestion: Differences in blood acetaldehyde concentrations in relatives of alcoholics and controls. Science 203, 54–55 (1979)

  17. Schulz, W., Kreuzberg, S., Neymeyer, H. G., Schwarz, U., Pachaly, A.: Über die Häufigkeit der atypischen ADH in Leberbiopsiematerial und den Einfluß auf den Äthanolumsatz in vivo. Kriminalistik und forensische Wissenschaften 26, 109–111 (1976)

  18. Smith, M., Hopkinson, D. A., Harris, H.: Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH1, ADH2 and ADH3. Ann. Hum. Genet. 37, 49–67 (1973)

  19. Stamatoyannopoulos, G., Chen, S. H., Fukui, F.: Liver alcohol dehydrogenase in Japanese: High population frequency of atypical form and its possible role in alcohol sensitivity. Am. J. Hum. Genet. 27, 789–796 (1975)

  20. Truit, E. B., Walsh, M. J.: The role of acetaldehyde in the actions of ethanol. In: The biology of alcoholism, B. Kissin, H. Begleiter (eds.), vol. 1, pp. 161–195, New York: Plenum Press 1971

  21. Von Wartburg, J. P., Papenberg, J., Aebi, H.: An atypical human alcohol dehydrogenase. Can. J. Biochem. 43, 889–898 (1965)

  22. Wilson, J. R., McClearn, G. E., Johnson, R. C.: Ethenic variation in use and effects of alcohol. Drug and Alcohol Dependence 3, 147–151 (1978)

  23. Wolff, P. H.: Ethenic differences in alcohol sensitivity. Science 175, 449–450 (1972)

  24. Wolff, P. H.: Vasomotor sensitivity to alcohol in diverse Mongoloid populations. Am. J. Hum. Genet. 25, 193–199 (1973)

  25. Zeiner, A. R., Paredes, A., Cowden, L.: Physiologic responses to ethanol among Tarahumara Indians. Ann. NY Acad. Sci. 273, 151–158 (1976)

  26. Zeiner, A. R., Parades, A., Christensen, D. H.: The role of acetaldehyde in mediating reactivity to an acute dose of ethanol among different racial groups. Alcoholism: Clin. Exp. Res. 3, 11–18 (1979)

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Correspondence to H. W. Goedde.

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Goedde, H.W., Harada, S. & Agarwal, D.P. Racial differences in alcohol sensitivity: A new hypothesis. Hum Genet 51, 331–334 (1979). https://doi.org/10.1007/BF00283404

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Keywords

  • Alcohol
  • Acetaldehyde
  • Internal Medicine
  • Aldehyde
  • Metabolic Disease