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Copolymer of sucrose and naphthoquinone imine derivatives

Synthesis and characterization

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Summary

The purpose of the present work was to prepare a macromolecular prodrug with methacrylic esters of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine(I) and those of suorose. The copolymer IV obtained by a bulk copolymerization reaction was purified by GPC and characterized by infrared spectroscopy, differential scanning calorimetry and hydrolysis studies. Its alkaline hydrolysis led to compound I which exhibited trypanocidal activity against T.cruzi.

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Author information

Correspondence to M. Martínez de Bertorello.

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Castellano, P., de Bertorello, M.M. Copolymer of sucrose and naphthoquinone imine derivatives. Polymer Bulletin 22, 41–45 (1989). https://doi.org/10.1007/BF00283282

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Keywords

  • Polymer
  • Spectroscopy
  • Ester
  • Hydrolysis
  • Sucrose