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Copolymer of sucrose and naphthoquinone imine derivatives

Synthesis and characterization

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The purpose of the present work was to prepare a macromolecular prodrug with methacrylic esters of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine(I) and those of suorose. The copolymer IV obtained by a bulk copolymerization reaction was purified by GPC and characterized by infrared spectroscopy, differential scanning calorimetry and hydrolysis studies. Its alkaline hydrolysis led to compound I which exhibited trypanocidal activity against T.cruzi.

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  1. 1.

    Karel Dusek, Ed., “Polymers in Medicine”, Springer Verlag, 53(1984).

  2. 2.

    R.S.Langer, “Medical Applications of Controlled Release”, CRC Press, Vol. I, 104(1984).

  3. 3.

    A.E.Fernández, M.M.de Bertorello, R.H.Manzo, Anales Asoc.Quím.Argentina, 70, 49(1982).

  4. 4.

    P.Amuchástegui, B.Basso, E.Moretti, N.Sperandeo, M.M.de Bertorello and M.C.Briñón, IV Jornadas Científicas de la Sociedad de Biología de Córdoba, Mayo 1987, Córdoba, Argentina.

  5. 5.

    P.Amuchástegui, E.Moretti, B.Basso, N.Sperandeo, M.W.de Bertorello and M.C.Briñón, Reunión Anual de la Sociedad Argentina de Protozoología, Octubre 1988, Córdoba, Argentina.

  6. 6.

    E.M.Pahn, N.P.Molina Portela, A.O.M.Stoppani, Revista Argentina de Microbiología, 20, 107–118(1988).

  7. 7.

    M.N.Schwarz de Tarlorusky, S.G.Goijman, A.O.M.Stoppani, Revista Argentina de Microbiología, 20, 183–194(1988).

  8. 8.

    M.A.Pastoriza, H.E.Bertorello, Proceeding of the “Third International Meeting on Polymer Sciences and Technology” p234–23B(1981). Literature Schnelldienst Kunststoffe-Kautschuck-Faser 6, 62(1982).

  9. 9.

    M.A.Pastoriza, H.E.Bertorello, Polym.Bull. 15, 241(1986).

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Correspondence to M. Martínez de Bertorello.

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Castellano, P., de Bertorello, M.M. Copolymer of sucrose and naphthoquinone imine derivatives. Polymer Bulletin 22, 41–45 (1989). https://doi.org/10.1007/BF00283282

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  • Polymer
  • Spectroscopy
  • Ester
  • Hydrolysis
  • Sucrose