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Gametic equilibrium of four loci on chromosome 1

Summary

The present study is the first to investigate gametic disequilibrium of loosely linked loci (recombination >22%) of known map distance in humans. The study population consisted of 302 healthy unrelated individuals of white mixed-European ancestry living in the Denver, Colorado area. Pairwise combinations of four loci on chromosome 1 (Rhesus, Duffy, phosphoglucomutase-1, and amylase-2) were examined for nonrandom association of alleles at different loci. Observed and expected values were compared with chi-square goodness-of-fit tests. There was no evidence of first-order interaction, i.e., gametic disequilibrium. From these findings it seems that gametic disequilibrium may not be important in the genetic organization of chromosome 1.

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References

  1. Brown AHD (1975) Sample sizes required to detect linkage disequilibrium between two or three loci. Theor Popul Biol 8:184–201

  2. Cadien JD, Hassett MJ, Friedlaender JS (1978) Linkage disequilibrium in Bougainville Island. Am J Phys Anthropol 48:297–304

  3. Finaz C, Nguyen CV, Cochet C, Frézal J, Grouchy J de (1977) Fiftty-million-year evolution of chromosome 1 in the primates: evidence from banding and gene mapping. Cytogenet Cell Genet 18:160–164

  4. Franklin I, Lewontin RC (1970) Is the gene the unit of selection. Genetics 65:707–734

  5. Hill WG (1975) Tests for association of gene frequencies at several loci in random mating diploid populations. Biometrics 31:881–888

  6. Lewontin RC (1964) The interaction of selection and linkage. I. General considerations; Heterotic models. Genetics 49:49–67

  7. Lewontin RC (1965) The role of linkage in natural selection. In: Geerts SJ (ed) Genetics Today, vol III. Pergamon Press, Oxford, pp 517–527

  8. Lewontin RC, Kojima K (1960) The evolutionary dynamics of complex polymorphisms. Evolution 14:458–472

  9. Meyers DA, Merritt AD, Conneally PM, Norton JA Jr, Rivas ML, Yu PL, Palmer CG (1978) Linkage group I: a statistically significant locus order from family studies. Cytogenet Cell Genet 22:396–400

  10. Smouse PE (1974) Likelihood analysis of recombinational disequilibrium in multiple-locus gametic frequencies. Genetics 76:557–565

  11. Spencer N, Hopkinson DA, Harris H (1964) Phosphoglucomutase polymorphism in man. Nature 204:742–745

  12. Spiess EB (1977) Genes in populations. John Wiley and Sons, New York

  13. Thomson G (1977) The effect of a selected locus on linked neutral loci. Genetics 85:753–788

  14. Thomson G, Bodmer WF, Bodmer J (1976) The HL-A system as a model for studying the interaction between selection, migration and linkage. In: Karlin S, Nevo E (eds) Population genetics and ecology. Academic Press, New York, pp 465–498

  15. Turner JRG (1969) Epistatic selection in the rhesus and MNS blood groups. Ann Hum Genet 33:197–206

  16. Weir BS, Cockerham CC (1978) Testing hypotheses about linkage disequilibrium with multiple alleles. Genetics 88:633–642

  17. Yasuda N (1978) The sampling variance of the linkage disequilibrium parameter in multi-allelic loci. Heredity 41:155–163

  18. Zouros E, Golding GB, MacKay TFC (1977) The effect of combining alleles into electrophoretic classes on detecting linkage disequilibrium. Genetics 85:543–550

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Gottlieb, K. Gametic equilibrium of four loci on chromosome 1. Hum Genet 58, 429–431 (1981). https://doi.org/10.1007/BF00282830

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Keywords

  • Nonrandom Association
  • Gametic Disequilibrium
  • Healthy Unrelated Individual
  • Theor Popul Biol
  • Haplotype Minus