The present study is the first to investigate gametic disequilibrium of loosely linked loci (recombination >22%) of known map distance in humans. The study population consisted of 302 healthy unrelated individuals of white mixed-European ancestry living in the Denver, Colorado area. Pairwise combinations of four loci on chromosome 1 (Rhesus, Duffy, phosphoglucomutase-1, and amylase-2) were examined for nonrandom association of alleles at different loci. Observed and expected values were compared with chi-square goodness-of-fit tests. There was no evidence of first-order interaction, i.e., gametic disequilibrium. From these findings it seems that gametic disequilibrium may not be important in the genetic organization of chromosome 1.
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Gottlieb, K. Gametic equilibrium of four loci on chromosome 1. Hum Genet 58, 429–431 (1981). https://doi.org/10.1007/BF00282830
- Nonrandom Association
- Gametic Disequilibrium
- Healthy Unrelated Individual
- Theor Popul Biol
- Haplotype Minus