Mapping of the DNA from 14 Mediterranean subjects indicates a genetic variation in an Hinf I recognition site located 1 kilobase 5′ to the β-globin gene. This Hinf I site was found associated with eight β-thalassemic genes and 11 normal β genes, and hence is not specifically linked to β-thalassemia.
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Kohen, G., Philippe, N. & Godet, J. Polymorphism of the Hinf I restriction site located 1 Kb 5′ to the human β-globin gene. Hum Genet 62, 121–123 (1982). https://doi.org/10.1007/BF00282298
- Internal Medicine
- Genetic Variation
- Metabolic Disease
- Restriction Site
- Recognition Site