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The same “TATA” box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Summary

A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

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Correspondence to Haig H. Kazazian Jr..

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Huang, S., Wong, C., Antonarakis, S.E. et al. The same “TATA” box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation. Hum Genet 74, 162–164 (1986). https://doi.org/10.1007/BF00282081

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Keywords

  • Internal Medicine
  • Ethnic Group
  • Metabolic Disease
  • Thalassemia
  • Independent Origin