Human Genetics

, Volume 74, Issue 2, pp 155–159 | Cite as

Regional localisation of X chromosome short arm probes

  • Karin Paulsen
  • Susan Forrest
  • G. Scherer
  • H. -H. Ropers
  • Kay Davies
Original Investigations


Nine human X chromosome-specific clones have been isolated by screening an X-chromosomal genomic library with fetal muscle cDNA. Five of the clones have been localised to the short arm and four to the long arm. The short arm probes have been regionally assigned using a panel of somatic cell hybrids. They have been mapped further using a series of DNA samples from male patients with different deletions of the region Xp21, and having complex phenotypes including Duchenne muscular dystrophy. The use of these probes in the mapping of the short arm of the X chromosome is discussed.


Internal Medicine Metabolic Disease Male Patient Somatic Cell Regional Localisation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Karin Paulsen
    • 1
  • Susan Forrest
    • 2
  • G. Scherer
    • 1
  • H. -H. Ropers
    • 3
  • Kay Davies
    • 2
  1. 1.Institut für Humangenetik der UniversitätFreiburgFederal Republic of Germany
  2. 2.Nuffield Department of Clinical MedicineJohn Radcliffe HospitalOxfordUK
  3. 3.Anthropogenetisch InstitutKatholieke UniversiteitNijmegenThe Netherlands

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