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α-Thalassemia haplotypes in the Algerian population

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Summary

DNA mapping was performed in seven unrelated HbH patients and nine carriers for α-thalassemia trait originating from Algeria. This study has allowed us to identify four α-thalassemia haplotypes: the (−α3.7) haplotype, which is the most frequent (18 of 23 α-thalassemic chromosomes), the (−(α)20.5) haplotype, a (--) haplotype, and an (αα)T haplotype. Our results also show that the (−α3.7) haplotypes encountered in the Algerian population are heterogeneous and differ by the site of the unequal crossover responsible for the 3.7-kb deletion and the size of the interzeta fragment. In addition, during this survey we observed that normal chromosomes bearing a polymorphic BglII site are associated with different interzeta fragments.

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Correspondence to J. Godet.

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Henni, T., Morlé, F., Lopez, B. et al. α-Thalassemia haplotypes in the Algerian population. Hum Genet 75, 272–276 (1987). https://doi.org/10.1007/BF00281073

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Normal Chromosome
  • Algerian Population
  • Unequal Crossover