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Kinetics of cholinesterase inhibition by eptastigmine in man

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  1. 1.

    Steel K, Feldman RG (1979) Diagnosing dementia and its treatable causes. Geriatrics 34: 79–88

  2. 2.

    Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR (1982) Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215: 1237–1239

  3. 3.

    Reisine TD, Yamamura HI, Bird ED, Spokes E, Enna SJ (1978) Pre- and postsynaptic neurochemical alterations in Alzheimer's disease. Brain Res 149: 447–481

  4. 4.

    Davis KL, Mohs RC (1982) Enhancement of memory processes in Alzheimer's disease with multiple dose intravenous physostigmine. Am J Psychiat 139: 1421–1424

  5. 5.

    Schwartz AS, Kohlstaedt EV (1986) Physostigmine effects in Alzheimer's diseases: Relationship to dementia severity. Life Sci 38: 1021–1028

  6. 6.

    Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A (1986) Oral tetrahydroaminoacridine in long-term treatment of senile dementia of the Alzheimer type. N Engl J Med 315: 1241–1245

  7. 7.

    Brufani M, Marta M, Pomponi M (1986) Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia. Eur J Biochem 157: 115–120

  8. 8.

    De Sarno P, Pomponi M, Giacobini E, Tang XC, Williams E (1989) The effect of heptyl-physostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat. Neurochem Res 14: 971–977

  9. 9.

    Brufani M, Castellano C, Marta M, Oliverio A, Pagella PG, Pavone F, Pomponi M, Rugarli PL (1987) A long-lasting cholinesterase inhibitor affecting neural and behavioral processes. Pharm Biochem Behav 26: 625–629

  10. 10.

    Marta M, Castellano C, Oliverio A, Pavone F, Pagella PG, Brufani M, Pomponi M (1988) New analogs of physostigmine: alternative drugs for Alzheimer's disease? Life Sci 43: 1921–1928

  11. 11.

    Oliverio A, Castellano C, Iacopino C, Pavone F, Brufani M, Marta M, Pomponi M (1986) Effects of physostigmine derivatives on cerebral cholinergic functions and their possible use in Alzheimer disease. In: Biggio G, Spano PF, Toffano G and Gessa GL (eds) Modulation of Central and Peripheral Transmitter Function. Liviana Press, Padova, pp 305–309

  12. 12.

    Johnson CD, Russel RL (1975) A rapid, simple radiometric assay for cholinesterase, suitable for multiple determination. Anal Biochem 64: 229–238

  13. 13.

    Becker RE, Giacobini E (1988) Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: clinical, pharmacological and therapeutic aspects. Drug Dev Res 12: 163–195

  14. 14.

    Becker RE, Colliver J, Elble R, Feldman E, Giacobini E, Kumar V, Markwell S, Moriearty P, Parks R, Shillcutt SD, Unni LK, Vicori S, Womack C, Zec R (1990) Effects of metrifonate, a long-acting cholinesterase inhibitor in Alzheimer disease: Report of an open trial. Drug Dev Res 19: 425–434

  15. 15.

    Lawrence GD, Yatim N (1990) Extraction of physostigmine from biologic fluids and analysis by liquid chromatography with electrochemical detection. J Pharmacol Methods 24: 137–143

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Unni, L.K., Hutt, V., Imbimbo, B.P. et al. Kinetics of cholinesterase inhibition by eptastigmine in man. Eur J Clin Pharmacol 41, 83–84 (1991).

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Key words

  • Eptastigmine
  • cholinesterase inhibitor
  • Alzheimer's disease
  • pharmacokinetics
  • adverse effects