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Model identification and estimation of organ-function parameters using radioactive tracers and the impulse-response function

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Abstract

Examination of the input-output events in functioning organs by the use of the impulse-response function (IRF) for a radioactive tracer is gaining more and more ground in nuclear medicine. This study summarizes the development of deconvolution analysis, laying special stress on the ‘model-free’ approach. System linearity and time invariance are discussed, and means of eliminating noise in IRFs originating from the input and organ-time-activity curves are outlined. Typical IRFs are illustrated by flow diagrams, time-domain curves, and their representation by Laplace transforms. The cases of nondiffusible and diffusible tracers as well as parenchymally extracted and transported substances are discussed. Methods for the derivation of models and for the calculation of physiologically important parameters from theIRFs are suggested.

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Correspondence to Dr. Zsolt Szabó.

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At present, a guest scientist at the Institute for Medicine, Nuclear Research Center Jülich, Jülich, Federal Republic of Germany

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Szabó, Z., Vosberg, H., Sondhaus, C.A. et al. Model identification and estimation of organ-function parameters using radioactive tracers and the impulse-response function. Eur J Nucl Med 11, 265–274 (1985). https://doi.org/10.1007/BF00279082

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Key words

  • Impulse response function
  • Transferfunction
  • Model identification
  • Tracer kinetics