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Zum praktischen Wert des Lymphozytenmodells für die pathogenetische Beurteilung einzelner Serumcholesterinfraktionen des Menschen bei der autosomal-monogenen Hypercholesterinämie

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Summary

The significance of genetic factors contributing to the complex etiology of coronary heart disease is discussed using lipoprotein metabolism as an example. A radiochemical screening method was developed for precise biochemical diagnosis of autosomal monogenic hypercholesterolemia. In this method lymphocytes are used as test material.

Zusammenfassung

Am Beispiel des Lipoproteinstoffwechsels wird die Bedeutung genetischer Teilfaktoren aus dem Ursachenkomplex der koronaren Herzkrankheit herausgestellt. Zur exakten biochemischen Diagnose der autosomal-monogenen Hypercholesterinämie wurde ein radiochemisches Screeningverfahren am Lymphozytenmodell erarbeitet und bei Infarktpatienten erprobt.

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Correspondence to Th. Wichmann.

Additional information

Ein Erratum zu diesem Beitrag ist unter http://dx.doi.org/10.1007/BF00282843 zu finden.

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Wichmann, T., Freye, H.-. & Berndt, K. Zum praktischen Wert des Lymphozytenmodells für die pathogenetische Beurteilung einzelner Serumcholesterinfraktionen des Menschen bei der autosomal-monogenen Hypercholesterinämie. Hum Genet 57, 285–289 (1981). https://doi.org/10.1007/BF00278946

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