The distribution of Gc subtypes in a sample of the Chinese population of Hong Kong was studied using isoelectric focusing followed by immunofixation. A sensitive modification of this technique is described. Nine distinct phenotypes were observed which appear to result from the three common alleles Gc IF, Gc IS, and Gc 2, which are found in most populations. The respective gene frequencies were 0.494, 0.258, and 0.247. In addition, two rare phenotypes were observed which appear to be due to a rare allele tentatively identified as Gc 2G2.
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Cleve H, Paluschnik W (1979) Neuraminidase treatment reveals scialic acid differences in certain genetic variants of the Gc system (vitamin D-binding protein). Hum Genet 47:193–198
Constans J, Cleve H (1979) Group-specific component report on the First International Workshop. Hum Genet 48:143–149
Constans J, Viau M (1977) Group-specific component: Evidence for two subtypes of the Gc1 gene. Science 198:1070–1071
Constans J, Viau M, Cleve H, Jaeyer G, Quilici JC, Palisson MJ (1978a) Analysis of the Gc polymorphism in human populations on polyacrylamide gels. Demonstration of subtypes of the Gc1 allele, and of additional variants. Hum Genet 41:53–60
Constans J, Viau M, Pison G, Langley A (1978b) Gc subtypes demonstrated by iso-electric focusing: further data and description of new variants among an African sample (Fula) from Senegal. Jpn J Hum Genet 23:111–117
Daiger SP, Schanfield MS, Cavalli-Sforza LL (1975) Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci 72:2076–2080
Hoste B (1979) Group-specific component (Gc) and transferin (Tf) subtypes ascertained by iso-electric focusing. Hum Genet 50:75–79
Kühnl P, Spielman W, Loa M (1978) An improved method of the identification of Gc1 subtypes (group-specific component) by isoelectric focusing. Vox Sang 35:401–404
Omoto K, Miyake K (1978) The distribution of the group-specific component (Gc) subtypes in Japanese. Jpn J Hum Genet 23: 119–125
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Kwok, K.Y.Y., Lewis, W.H.P. Group-specific component (Gc) subtypes in the Chinese population of Hong Kong. Hum Genet 59, 72–74 (1981). https://doi.org/10.1007/BF00278858
- Chinese Population
- Rare Allele
- Neuraminidase Treatment
- Rare Phenotype