Chromosomally normal and trisomy-21 individuals were studied for the ability of their nucleolus-organising chromosomes to form satellite associations in G-banded lymphocyte metaphases. Two types of parameter, absolute association frequency and relative association frequency, were used. There was no significant difference between females and males or between Caucasoids and Mongoloids for either type of association parameter in the controls, nor was there significant correlation between age (17–40 years) and either type of parameter in the controls.
The pattern of two chromosome associations is accounted for by two related models in both normal and trisomic individuals. These models imply that there is an extensive polymorphism for associating ability and that this ability may be zero in individual chromosomes. Homologous do not associate preferentially with each other. The absolute frequency of acrocentric association is lower in trisomy 21 individuals than disomic controls, but the relative involvement of chromosome 21 (after correction for the trisomic state) is higher than in the controls.
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Ardito G, Lambert L, Brogger A (1978) Satellite associations of human acrocentric chromosomes identified by trypsin treatment at metaphase. Ann Hum Genet 41:455–462
Back E, Zang KF (1969) Quantitative studies on the arrangement of human metaphase chromosomes. Cytogenetics 8:304–314
Cohen MM, Shaw MW (1967) The association of acrocentric chromosomes in 1000 normal human male metaphase cells. Ann Hum Genet 31:129–140
Cooke P (1971) Non-random participation of chromosomes 13, 14 and 15 in acrocentric association. Humangenetik 13:309–314
Cuevas-Sosa A (1970) Human chromosomology: Random association of acrocentrics. Genetica 41:626–634
Ferguson-Smith MA, Handmaker SD (1961) Observations on the satellited human chromosomes. Lancet I:638–640
Hansson A (1979) Satellite association in human metaphases. A comparative study of normal individuals, patients with Down syndrome and their parents. Hereditas 90:59–83
Hansson A (1975) Compensatory mechanisms in the satellite association patterns of individuals with Robertsonian translocations. Hereditas 81:101–112
Hayata I, Oshimura M, Sandberg AA (1977) N-Band polymorphism of human acrocentric chromosomes and its relevance to satellite association. Hum Genet 36:55–61
Henderson AS, Warburton D, Atwood KC (1973) Ribosomal DNA connectives between human acrocentric chromosomes. Nature 245:95–97
Hoehn H, Nagel M, Krone W (1971) In vitro alteration of association patterns of human acrocentric chromosomes. Humangenetik 11: 146–154
Jacobs PA, Mayer M, Morton NE (1976) Acrocentric chromosome association in man. Am J Hum Genet 28:567–576
Liem SL, Denton TE, Cheng KM (1977) Distribution patterns of satellite association in human lymphocytes relative to age and sex. Clin Genet 12:104–110
Lubs HA, Ruddle FH (1971) Chromosome polymorphism in American Negro and White populations. Nature 233:134–136
Mattei JF, Ayme S, Mattei MG, Gourvernet J, Giraud F (1976) Quantitative and qualitative study of acrocentric association in 109 normal subjects. Hum Genet 34:185–194
Mattevi MS, Salzano FM (1975) Effect of sex, age and cultivation time on number of satellites and acrocentric associations in man. Humangenetik 29:265–270
Miller DA, Dev VG, Tantravahi R, Miller OJ (1976) Suppression of human nucleolus organiser activity in mouse-human somatic hybrid cells. Exp Cell Res 101:235–243
Miller DA, Tantravahi R, Dev VG, Miller OJ (1977) Frequency of satellite association of human chromosomes is correlated with amount of Ag-staining of the nucleolus organiser region. Am J Hum Genet 29:490–502
Miller OJ, Miller DA, Dev VG, Tantravahi R, Croce CM (1976) Expression of human and suppression of mouse nucleolus organiser activity in mouse-human somatic hybrid cells. Proc Natl Acad Sci USA 73:4531–4535
Nankin HR, (1970) In vitro alteration of satellite association and nucleolar persistence in mitotic human lymphocytes. Cytogenetics 9:42–51
Nilsson C, Hansson A, Nilsson G (1975) Influence ofthyroid hormones on satellite association in man and the origin of chromosome abnormalites. Hereditas 80:157–166
Patil SR, Lubs HA (1971) Non-random association of human acrocentric chromosomes. Humangenetik 13:157–159
Prokofieva-Belgovskaya AA, Grindilis VM, Grinberg KN, Bogomazov EA, Podugolnikova OA, Isaeva II, Radjabli SI, Cellarius SP, Vischneva IV (1968) Association of acrocentric chromosomes in relation to cell type and age of individuals. Exp Cell Res 49:612–625
Rosenkranz W, Fleck S (1969) Die Bedeutung der Association satellitentragender Chromosomen. Humangenetik 7:9–21
Rosenkranz W, Holzer S (1972) Satellite association. A possible cause of chromosome aberrations. Humangenetik 16:147–150
Schmid M, Krone W, Vogel W (1974) On the relationship between the frequency of association and nucleolar constriction of individual acrocentric chromosomes. Humangenetik 23:267–277
Warburton D, Atwood KC, Henderson AS (1976) Variation in the number of genes for rRNA among human acrocentric chromosomes: correlation with frequency of satellite association. Cytogenet Cell Genet 17:221–230
Zankl H, Zang KD (1974) The association frequency of human acrocentric marker chromosomes. Humangenetik 23:259–265
Zellweger H, Abbo G, Cuany R (1966) Satellite association and translocation mongolism. J Med Genet 3:186–189
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Yip, M., Fox, D.P. Variation in pattern and frequency of acrocentric association in normal and trisomy-21 individuals. Hum Genet 59, 14–22 (1981). https://doi.org/10.1007/BF00278848
- Homologous Class
- Association Frequency
- Association Parameter
- Satellite Chromosome
- Satellite Association