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Repeated DNA sequences in the distal long arm of the human X chromosome

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Summary

Two DNA probes from within a single large insert from a recombinant phage-DNA library that was constructed from flow-sorted chromosomes enriched for the human X chromosome were shown to hybridize with repeated X-specific and autosomal DNA sequences. The X-chromosomal repeated sequences were assigned to the distal long arm of the X chromosome by both hybrid mapping and in situ hybridization. Fine mapping places these repeats in a region of Xq28 between DX13 (DXS15, in distal Xq28) and factor VIII (F8C, in proximal Xq28). The location of the X-specific repeats makes them potentially useful for future investigations of discases mapping to the distal long arm of the X chromosome, such as the fragile X syndrome.

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Correspondence to U. Müller.

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Müller, U., Tantravahi, U., Monaco, A. et al. Repeated DNA sequences in the distal long arm of the human X chromosome. Hum Genet 74, 24–29 (1986). https://doi.org/10.1007/BF00278780

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Repeated Sequence
  • Factor VIII
  • Fine Mapping