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An autoradiographic study of bone grafts in small animals


Bone remodelling was studied in allografts and isografts by means of autoradiography. Collagen and proteglycanes of the organic bone matrix were labelled with H-3 aminoacids and S-35 sodium sulphate. The principles of primary bone formation are followed in graft remodelling as well. Matrix breakdown and reformation are carried out by mononuclear cells. Components of the original matrix can be seen in osteoclasts, perivascular cells, osteoblasts, young osteocytes, and in new bone. The label allows tracing of these components and proves their reuse.

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Correspondence to Dr. Kurt Udo Tiedjen.

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Hildmann, H., Tiedjen, K.U. & Hildmann, A. An autoradiographic study of bone grafts in small animals. Eur J Nucl Med 12, 147–150 (1986).

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Key words

  • Bone grafts
  • Autoradiography
  • Animal study