Displacements of the bromide space (Br-82-C, as a marker for the extracellular fluid compartment) are caused by an enhanced anatomical space and/or increased permeability of cells to bromide. The ratio Br-82-C: total body water (TBW) was evaluated to be 0.83±0.17 in critically ill patients (n=38) compared with the normal value of 0.46±0.04 (n=10). Because of normal TBW in critically ill patients (TBW=505±68 ml/kg), an increased bromide penetration into cells seems to be responsible for the enlarged ratio Br-82-C: TBW. Taking into consideration measurements in patients with malabsorption (Br-82-C: TBW=0.56±0.13; n=13) and carcinoma of the rectum and colon (Br-82-C: TBW=0.66±0.24; n=18) we think that the bromide space is a good measurement of the effective extracellular water.
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Bauer JH, Burt RW, Whang R, Grim CE (1975) Simultaneous determination of extracellular fluid and total body water I. J Lab Clin Med 86:1003–1008
Elwyn DH, Bryan-Brown CW, Shoemaker WC (1975) Nutritional aspects of body water dislocations in postoperative and depleted patients. Ann Surg 182:76–85
Flear CTG, Singh CM (1973) Hyponatraemia and sick cells. Br J Anaest 45:976–994
Hanson GC (1975) The management of acute disorders of fluid and electrolyte balance. In: Hanson GC, Wright PL (eds) The medical management of the critically ill. Academic Press, London, pp 158–188
Lehr L, Schober O, Pichlmayr R (1980) Assessment of total body potassium and water for therapeutic control of maldigestion syndromes. Langenbecks Arch Suppl 83–88
Moore FD (1963) The body cell mass and its supportive environment. WB Saunders, Philadelphia
Nicholsen JP, Zilva JF (1960) Estimation of extracellular fluid volume using radiobromide. Clin Sci 19:391–398
Nie NH, Rull Ch, Jenkins JG, Steinbrenner K, Bent DH (1975) SPSS; Statistical Package for the Social Sciences. McGraw Hill, New York
Omvik P, Tarazi RC, Bravo EL (1979) Determination of extracellular fluid volume in uremic patients by oral administration of radiosulfate. Kidney Int 15:71–79
Overman RR (1946) Permeability alterations in disease. J Lab Clin Med 31:1170–1173
Patrick J (1977) Assessment of body potassium stores. Kidney Int 11:476–490
Patrick J, Reeds PJ, Jackson AA, Seakins A, Picou DIM (1978) Total body water in malnutrition: the possible role of energy intake. Br J Nutr 39:417–424
Schober O, Mariss P, Schmidt FW, Hundeshagen H (1979) Total body water, extracellular water, plasma volume, and total body potassium in cirrhosis of the liver. Klin Wochenschr 57:757–761
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Schober, O., Lehr, L. & Hundeshagen, H. Bromide space, total body water, and sick cell syndrome. Eur J Nucl Med 7, 14–15 (1982). https://doi.org/10.1007/BF00275238
- Public Health
- Body Water