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A new polymorphic variant of human complement factor I

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Summary

Sera from 305 individuals were typed for factor I, and a new variant, tentatively designated FI* C, was found. All other samples were FIB except for seven samples from Chinese that were of the FI AB phenotype. This suggests that polymorphism of factor I may be rare in Caucasians.

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References

  1. Nakamura S, Abe K (1985) Genetic polymorphism of human factor I (C3b inactivator). Hum Genet 71:45–48

  2. Nishimukai H, Tamaki Y (1986) I (C3b/C4b inactivator) typing by agarose gel isoelectric focusing and immunoblotting technique. Hum Hered 36:195–197

  3. Yuasa I, Umetsu K, Suenaga K, Ito K, Iha M, Hirata H, Robinet-Levy M, Inoue T, Okada K (1988) Factor I (C3b inactivator) polymorphism among five populations in Eurasia. Hum Hered 38:91–94

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Author information

Correspondence to Ming Zhou.

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Zhou, M., Larsen, B. A new polymorphic variant of human complement factor I. Hum Genet 82, 393 (1989). https://doi.org/10.1007/BF00274006

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Sera
  • Complement Factor
  • Polymorphic Variant