Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The development of the antigenic structures of human α1-antichymotrypsin and C 1 q

  • 17 Accesses

  • 1 Citations

Summary

The cross-reactions of human α1-antichymotrypsin and C 1 q with their homologues in the plasmas of the chimpanzee, several Old World monkeys and nine non-primate eutheria were investigated by standard procedures. The results show that cross-reactions are limited to the first species mentioned. Comparative Ouchterlony tests and absorption controls revealed the presence of two (human) determinants on both human and chimpanzee molecules, while the cercopithecoids analyzed carried only one of them on their homologue. The results are discussed briefly with reference to earlier findings from this laboratory.

Zusammenfassung

Die Kreuzreaktionen des menschlichen α1-Antichymotrypsin und des C 1 q mit seinen Homologen im Plasma des Schimpansen, einiger Altweltaffen und demjenigen von 9 Nichtprimaten (Eutheria) wurden mit Standardmethoden untersucht. Die Ergebnisse zeigen, daß Kreuzreaktionen auf die zuerst genannten Species beschränkt sind. Vergleichende Ouchterlony-Tests und Absorptionskontrollen ließen die Anwesenheit zweier („menschlicher”) Determinaten auf den Molekülen des Menschen und des Schimpansen erkennbar werden, während die untersuchten Cercopithecoidea nur eine dieser Determinanten besitzen. Die Ergebnisse werden kurz im Zusammenhang mit früheren Befunden aus unserem Laboratorium diskutiert.

This is a preview of subscription content, log in to check access.

References

  1. Bauer, K.: The antigenic determinants of several human plasma proteins. Their determination from the investigation of the cross-reactions between human and other mammalian plasmas. Int. J. Prot. Res. 2, 137–145 (1970a).

  2. Bauer, K.: Cross-reactions between human and animal plasma proteins. I. The immunological evolution groups (IEG) I and II. Humangenetik 8, 325–329 (1970b).

  3. Bauer, K.: An immunological time scale for primate evolution consistent with fossil evidence. Humangenetik 10, 344–350 (1970c).

  4. Bauer, K.: Cross-reactions and antigenic structures of human α1B-, α1T and Znα2-glycoproteins. Physiol. Chem. Physics 2, 587–589 (1970d).

  5. Bauer, K.: Age determination by immunological techniques of the last common ancestor of man and chimpanzee. Humangenetik 17, 253–265 (1973).

  6. Pauling, L., Pressman, D., Campbell, D. H.: The serological precipitation of simple substance containing the two corresponding haptenic groups. Evidence for the framework theory of serological precipitation. J. Amer. Chem. Soc. 66, 330 (1944).

Download references

Author information

Correspondence to Klausdieter Bauer.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bauer, K. The development of the antigenic structures of human α1-antichymotrypsin and C 1 q. Hum Genet 17, 267–270 (1973). https://doi.org/10.1007/BF00273639

Download citation

Keywords

  • Internal Medicine
  • Standard Procedure
  • Metabolic Disease
  • World Monkey
  • Absorption Control