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A new anticancer agent (LY186641) interferes with creatinine assay

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The administration of a diarylsulfonylurea, LY186641, which is presently undergoing a multicentric phase I clinical trial as an anticancer agent, produces major analytical interference with commonly used creatinine analysis techniques. We confirm that this interference is caused by a metabolite rather than the parent compound and propose an alternative, interference-free method.

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Correspondence to Marc M. Bonnay.

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Bonnay, M.M., Recondo, G., Gouyette, A.J. et al. A new anticancer agent (LY186641) interferes with creatinine assay. Cancer Chemother. Pharmacol. 23, 119–120 (1989). https://doi.org/10.1007/BF00273530

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  • Clinical Trial
  • Creatinine
  • Cancer Research
  • Anticancer Agent
  • Parent Compound