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Die Impulsregeneration bei der Signalfortleitung in markhaitigen Nervenfasern

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As regards the regeneration of nervous impulses the controlling mechanism of the excitable membrane can be reduced essentially to the following two membrane properties:

  1. 1.

    There is a fixed voltage interval where the two different positive conductivities of the membrane change over continuously. In this transition region if the membrane potential is more positive the current-voltage characteristic shows a negative differential resistance. This characteristic may be measured under steady-state conditions in the presence of the particular ions (K., Rb., and during veratridine-poisoning also Na., Li., NH4 ., C(NH2)3 .) acting as charge carriers during excitation.

  2. 2.

    In addition Na.—K.-selectitivity is observed which effects a faster penetration of Na. than of K. through the membrane.

At present the molecular basis of both properties is unknown. But each property can be changed independently of the other. Physicochemical means (e.g., variation of pH, osmolarity, solvent, concentration of bivalent cation) act unpon the shape of the current-voltage relation by shifting the transition region, while the selectivity is changed by the presence of pharmacological agents (local anaesthetics such as cocain, tetrodotoxin, veratridine). So it may be advantageous to localize and characterize the action on membrane structure common to all members of each group of agents in order to approach the molecular origin of the basic membrane properties.

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Müller-Mohnssen, H. Die Impulsregeneration bei der Signalfortleitung in markhaitigen Nervenfasern. Kybernetik 7, 207–221 (1970). https://doi.org/10.1007/BF00272656

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