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Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues

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Summary

A method of starch gel electrophoresis is described which enables detection of 6 isozymes of human pyruvate kinase (PK,E.C.2.7.1.40). Comparing the PK-isozyme patterns of 53 diverse human tumors with those of normal adult and fetal organ tissues, it was found that the isozyme PK I is predominant in all malignant tumors as well as in almost all fetal organs.

Zusammenfassung

Es wird eine Methode der Stärkegelelektrophorese beschrieben, die die Darstellung von 6 Isoenzymen menschlicher Pyruvatkinase (PK,E.C.2.7.1.40) ermöglicht. Ein Vergleich der PK-Isoenzymmuster von 53 verschiedenen menschlichen Tumoren mit denen von normalen adulten und fetalen Organgeweben zeigt das Vorherrschen des Isoenzyms PKI in allen malignen Tumoren und fast allen fetalen Organen.

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References

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Kamel, R., Schwarzfischer, F. Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues. Hum Genet 28, 65–69 (1975). https://doi.org/10.1007/BF00272484

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Keywords

  • Starch
  • Internal Medicine
  • Pyruvate
  • Malignant Tumor
  • Metabolic Disease