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Quantitative studies on the arrangement of human metaphase chromosomes

V. The association pattern of acrocentric chromosomes in human meningiomas after the loss of G and D chromosomes


The association pattern was studied in 2715 mitoses of 90 meningiomas with different numbers of acrocentric chromosomes. In cells with monosomy 22, a significant increase of mitoses with associations was observed in comparison to cells with a normal karyotype. The number of associating acrocentric chromosomes was highly significantly increased. This surplus was not only caused by a highly significant increase of associating G chromosomes but also of D chromosomes. The loss of further acrocentric chromosomes had no significant influence on the number of mitoses with associations or the number of associating chromosomes. Based on the well-known correlations between the nucleolus organization and the association pattern, the results seem to indicate a compensation mechanism among the nucleoles organizing regions (NOR's) which keeps the supply of nucleolar material constant and simultaneously causes a higher association tendency between the remaining acrocentric chromosomes. The increase of associations in the 22 monosomic cells was interpreted as a overcompensation after the loss of only one NOR.

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Zankl, H., Zang, K.D. Quantitative studies on the arrangement of human metaphase chromosomes. Hum Genet 40, 149–155 (1978).

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  • Internal Medicine
  • Metabolic Disease
  • Significant Influence
  • Meningioma
  • Quantitative Study