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Autoimmunity and chondrolysis of the hip

A report of two cases

Summary

Two patients with rapidly progressive chondrolysis of the hip are reported. Immunofluorescent staining showed deposits of immunoglobulins and complement components in the synovium and the remaining femoral head cartilage. Seven patients with osteoarthritis of the hip and knee, or femoral neck fractures, were used as controls and all had a negative immunofluorescent staining reaction in the synovium. We suggest that an autoimmune reaction against articular cartilage antigens may play a role in the development of chondrolysis.

Résumé

Deux patients présentant une chondrolyse rapide de la tête fémorale ont été examinés sur le plan histopathologique et immunohistologique. L'examen immunohistologique par immunofluorescence a montré des dépôts d'immunoglobulines et des composants du complément au niveau du tissu synovial et du cartilage restant de la tête fémorale. Sept malades atteints de coxarthrose, de gonarthrose et de fracture du col de fémur ont servi de témoins. Tous ces témoins ont été négatifs à la réaction par immunofluorescence. On est amené ainsi à supposer qu'une réaction auto-immune vis-à-vis du cartilage articulaire peut jouer un rôle dans la genèse de la chondrolyse.

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References

  1. 1.

    Bobechko WP (1973) Autoimmune reactions of articular cartilage. In: Delchef J, De Marneffe R, Vander Elst E (eds) Proceedings of the twelfth congress of the International Society of Orthopaedic Surgery and Traumatology, Series No. 291, Amsterdam, Excerpta Medica

  2. 2.

    Cooke TD, Bennet EL, Ohno O (1980) Identification of immunoglobulins and complement components in articular collagenous tissues of patients with idiopathic osteoarthrosis. In: Nuki G (ed) Aetiopathogenesis of osteoarthrosis. Kent, Pitman Med, Pub, pp 144–154

  3. 3.

    Eguro H, Goldner JL (1974) Antigenic properties of chondromucoprotein and inducibility of experimental arthritis by antichondro mucoprotein immune globulin. J Bone Joint Surg 56-A: 129–141

  4. 4.

    Eisenstein A, Rothschild S (1976) Biochemical abnormalities in patients with slipped capital femoral epiphysis and chondrolysis. J Bone Joint Surg 58-A: 459–467

  5. 5.

    Gertzbein SD, Tile M, Gross A, Falk R (1975) Autoimmunity in degenerative disc disease of the lumbar spine. Orthop Clin North Am 6: 67–73

  6. 6.

    Gertzbein SD, Tait JL, Devlin SR (1977) The Stimulation of lymphocytes by nucleus pulposus in patients with degenerative disk disease of the lumbar spine. Clin Orthop 123: 149–154

  7. 7.

    Lequesne M, De Seze S, Amouroux J (1970) La coxarthrose destructrice rapide. Rev Rhum 37: 721–733

  8. 8.

    Mankin HJ, Sledge CB, Rothschild S, Eisenstein A (1975) Chondrolysis of the hip. The Proceedings of the third open scientific meeting of the Hip Society, Mosby, pp 127–135

  9. 9.

    Mergenhagen SE, Wahl SM, Wahl LM, Horton JE, Raisz LG (1975) The role of lymphocytes and macrophages in the destruction of bone and collagen. NY Acad Sci 256: 132–140

  10. 10.

    Morrissy RT, Kalderon AE, Gerdes MH (1981) Synovial immunofluorescence in patients with slipped capital femoral epiphysis. J Pediatr Orthop 1: 55–60

  11. 11.

    Postel M, Kerboul M (1970) Total prosthetic replacement in rapidly destructive arthrosis of the hip joint. Clin Orthop 72: 138–144

  12. 12.

    Rajapakse DA, Bywater EGL (1974) Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis. Clin Exp Immunol 16: 497–502

  13. 13.

    Taplits MS, Crissman JD, Herman JH (1979) Histologic Assessment of lymphokine-mediated suppression of chondrocyte glycosaminoglycan synthesis. Arthritis Rheum 22: 66–70

  14. 14.

    Trentham DE, Townes AS, Kang AH (1977) Autoimmunity to type II collagen: An experimental model of arthritis. J Exp Med 146: 857–868

  15. 15.

    Trentham DE, Townes AS, Kang AH, David JR (1978) Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. J Clin Invest 61: 89–96

  16. 16.

    Yoshioka Y, Tawara T, Uda H (1977) Rapidly destructive Coxarthrosis: A Case Report. Hip Joint 3: 163–167

  17. 17.

    Yoshioka Y, Tsuru S, Yokoyama M, Nomoto K (1982) An experimental study on immunological reactions against the articular cartilage. Int Arch Allergy Appl Immunol 68: 152–156

  18. 18.

    Waldenström H (1930) On necrosis of the joint cartilage by epiphyseolysis captis femoris. Acta Chir Scand 67: 936–946

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Correspondence to Y. Yoshioka.

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Yoshioka, Y., Shichikawa, K. Autoimmunity and chondrolysis of the hip. International Orthopaedics 11, 289–293 (1987). https://doi.org/10.1007/BF00271463

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Key words

  • Chondrolysis
  • Autoimmune reaction
  • Cartilage antigen