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Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma


Since its first description by Kepes in 1979, pleomorphic xanthoastrocytoma (PXA) has been considered a tumor with a benign course. Two cases are presented here that support the concept that PXA may be more accurately considered part of a spectrum of astrocytomas that occasionally may act aggressively. These cases represent astrocytomas with PXA components and are characterized by meningeal proximity, a high number of mitoses, and subsequently aggressive clinical behavior. The importance of recognizing the potential of a “benign” PXA to transform into a malignant entity has obvious implications for the therapeutic management of these tumors.

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  1. 1.

    Kepes J (1979) Xanthomatous lesions of the central nervous system: definition, classification and some recent observations. In: Zimmerman HM (ed) Progress in neuropathology, vol 4. Raven Press, New York, pp 179–213

  2. 2.

    Kepes J, Rubenstein LJ (1980) Malignant gliomas with heavily lipidized (foamy) tumor cells: a report of three cases with immunoperoxidase study. Cancer 47:2451–2459

  3. 3.

    Kepes J, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with a relatively favorable prognosis. A study of 12 cases. Cancer 44:1839–1852

  4. 4.

    Kuhajda F, Mendelsohn G, Taxy J, Long D (1981) Pleomorphic xanthoastrocytoma: report of a case with light and electron microscopy. Ultrastruct Pathol 2:25–32

  5. 5.

    McKeever PE, Balentin JD (1987) Chapter 29. In: Speer SS (ed) Nervous system. Histochemistry in pathological diagnoses. Marcel Dekker, New York Basel, pp 871–879

  6. 6.

    Palua L, Maleci A, Di Lorenzo N, Lauro G (1985) Pleomorphic xanthoastrocytoma with 18-year survival. J Neurosurg 63:808–810

  7. 7.

    Rorke LB, Gilles FH, Davis RL, Becker LE (1985) Revisions of the World Health Organization Classification of Brain Tumors. Cancer 56:1869–1886

  8. 8.

    Rubenstein LJ (1972) Pumors of the central nervous system, Fascicle 6, Second series. Atlas of Tumor Pathology, American Forces Institute of Pathology, Bethesda

  9. 9.

    Weldon-Linne CM, Victor TA, Groothuis DR, Vick NA (1983) Pleomorphic xanthoastrocytoma: ultrastructure and immunohistochemical study of a case with a rapidly fatal outcome following surgery. Cancer 52:2055–2063

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Correspondence to Arthur E. Marlin.

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Gaskill, S.J., Marlin, A.E. & Saldivar, V. Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. Child's Nerv Syst 4, 237–240 (1988). https://doi.org/10.1007/BF00270921

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Key words

  • Pleomorphic xanthoastrocytoma
  • Astrocytoma
  • Tumor