Child's Nervous System

, Volume 2, Issue 3, pp 109–111 | Cite as

The concentrations of xanthine and hypoxanthine in cerebrospinal fluid as therapeutic guides in hydrocephalus

  • M. Castro-Gago
  • S. Lojo
  • R. Del Rio
  • A. Rodriguez
  • I. Novo
  • S. Rodriguez-Segade
Original Papers


Xanthine, hypoxanthine, and total oxypurine levels were determined in the cerebrospinal fluid of 18 hydrocephalic patients and 8 healthy controls by high-performance liquid chromatography (HPLC). Eight of the hydrocephalic patients were self-compensated and 10 had shunts implanted during the course of the study. The mean xanthine, hypoxanthine, and total oxypurine levels in the normal children were 5.20, 5.94 and 11.29 μmol/l, respectively. In self-compensated hydrocephalics these levels were respectively 6.06, 6.50 and 12.57 μmol/l. In noncompensated hydrocephalics, they were 11.40, 10.79 and 22.19 μmol/l. The differences between the latter group and the first two are statistically significant (P<0.001). Fifteen days after implantation of shunts in the noncompensated hydrocephalics, the mean xanthine levels had fallen to 4.61 μmol/l, the mean hypoxanthine levels to 5.03 μmol/l, and the mean total oxypurine levels to 9.64 μmol/l. The change is statistically significant (P<0.001). In light of these findings we propose that xanthine, hypoxanthine, and total oxypurine levels be used in cases of hydrocephalus as guides for therapeutic action and to monitor progress.

Key words

Hydrocephalus Cerebrospinal fluid Total oxypurines Xanthine Hypoxanthine Guanine 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Castro-Gago
    • 1
  • S. Lojo
    • 2
  • R. Del Rio
    • 2
  • A. Rodriguez
    • 1
  • I. Novo
    • 1
    • 2
  • S. Rodriguez-Segade
    • 2
  1. 1.Department of Pediatrics, Neuropediatrics ServiceUniversity of Santiago de CompostelaSantiago de CompostelaSpain
  2. 2.Central Laboratory Service, General Hospital de Galicia, School of MedicineUniversity of Santiago de CompostelaSantiago de CompostelaSpain

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