The mode of antirepressor action in anti-immune cells was analysed in respect to its two main features, low lysogenization and high cell killing. By means of complementation experiments between λ and λi434 in anti-immune cells, it was shown that the antirepressor no longer channels λ phages towards lysis in such cells if the genes which are needed for lysogenization are provided in trans by the heteroimmune phage λi434. Since complementation could be demonstrated, it was possible to exclude that direct action of the antirepressor over repressor production is responsible for the feature under analysis. It was also shown that both int- and cII-product are required to improve lysogenization and to prevent high levels of killing.
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Recipient of an EMBO predoctoral fellowship.
Communicated by G. Bertani
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Galland, P., Bassi, P. & Calef, E. On the mode of antirepressor action in anti-immune cells. Molec. Gen. Genet. 125, 231–239 (1973). https://doi.org/10.1007/BF00270745
- Cell Killing
- High Cell
- Direct Action
- Complementation Experiment
- Longe Channel