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Impairment of monocyte “lectin-like” receptor activity in Type 1 (insulin-dependent) diabetic patients

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Summary

In order to investigate whether the ability of peripheral blood monocytes to bind bacteria is impaired in diabetes, we studied carbohydrate-binding (“lectin-like”) receptors and the receptor for the Fc portion of immunoglobulin on monocytes from 25 male Type 1 (insulin-dependent) diabetic patients and 10 age-matched healthy control subjects. Peripheral blood monocytes from the diabetic patients expressed lower levels of “lectin-like” receptors compared to the control subjects, whereas the expression of the receptor for the Fc portion of immunoglobulin was similar in both populations. There was no correlation between the degree of “lectin-like” binding activity and plasma glucose concentration or glycaemic control. Recognition of unopsonized bacteria by the “lectin-like” receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens.

References

  1. 1.

    Gordon OP (1983) Morbidity and mortality from diabetes mellitus. A look at preventable aspects. Am J Pub Health 73: 1156–1158

  2. 2.

    Bagdade JD (1976) Phagocytic and microbicidal function in diabetes mellitus. Acta Endocrinol (Copenh) 83 [Suppl 205]: 27–33

  3. 3.

    Glass EJ, Stewart J, Weir DM (1986) Altered immune function in alloxan induced diabetes in mice. Clin Exp Immunol 65: 614–621

  4. 4.

    Unanue ER (1984) Antigen-presenting function of the macrophage. Ann Rev Immunol 2: 395–428

  5. 5.

    Ogmundsdottir HM, Weir DM (1976) The characteristics of binding of Corynebacterium parvum to glass-adherent mouse peritoneal exudate cells. Clin Exp Immunol 26: 334–339

  6. 6.

    Glass EJ, Stewart J, Weir DM (1981) Presence of bacterial binding “lectin-like” receptors on phagocytes. Immunology 44: 529–534

  7. 7.

    Stewart J, Glass EJ, Weir DM (1982) Macrophage binding of Staphylococcus albus is blocked by anti I-region alloantibody. Nature 298: 852–853

  8. 8.

    Boyum A (1968) Isolation of leukocytes from human blood. Further observations. Methyl cellulose, dextran and Ficoll as erythrocyte-aggregating agents. Scand J Clin Lab Invest 21 [Suppl 97]: 31–50

  9. 9.

    Read A, Tibi L, Smith AF (1980) Assessment of a simple electrophoretic method for measuring HbAl. Clin Chim Acta 108: 487–491

  10. 10.

    Johnson RN, Metcalf PA, Baker JR (1982) Fructosamine: a new approach to the estimation of glycosyl protein. An index of diabetic control. Clin Chim Acta 127: 87–95

  11. 11.

    Dougherty GJ, McBride WH (1984) Macrophage heterogeneity. J Clin Lab Immunol 14: 1–11

  12. 12.

    Brownlee M, Vlassara H, Cerami A (1984) Non-enzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 101: 527–537

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Glass, E.J., Stewart, J., Matthews, D.M. et al. Impairment of monocyte “lectin-like” receptor activity in Type 1 (insulin-dependent) diabetic patients. Diabetologia 30, 228–231 (1987). https://doi.org/10.1007/BF00270420

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Key words

  • Diabetes
  • monocytes
  • “lectin-like” receptors
  • bacterial recognition