Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Vascular response in fractured limbs with and without immobilisation: An experimental study on rabbits

  • 23 Accesses

  • 8 Citations

Summary

An experimental study was carried out on 24 rabbits in whom a fracture of the tibia was treated without plaster (group 1) and 24 rabbits in whom a plaster was applied to immobilise the fracture (group 2). The rabbits from each group were killed at varying intervals and the limbs were perfused with chromopaque so that the vascularity could be assessed by radiographs.

After fracture the vascular response in limbs increased gradually from the third day, reached a peak by the end of the second week and thereafter declined gradually. The capillaries around the fracture site proliferated by the second week. When plaster was not used (group 1) dilatation of the main artery was followed by proliferation of the small and medium-sized vessels and capillaries which persisted until the tenth week. In group 2 (plaster) the vascular pattern returned to normal by the seventh week. Excess callus and delayed union was present in group 1 whereas early union with less callus formation occurred in group 2.

Résumé

On a réalisé une étude expérimentale sur 24 lapins chez lesquels une fracture du tibia a été traitée sans plâtre (groupe 1) et sur 24 autres lapins qui ont bénéficié d'un plâtre immobilisant leur fracture (groupe 2). Les animaux des deux groupes ont été sacrifiés à intervalles variables et les pièces ont été perfusées avec un produit opaque permettant de visualiser radiologiquement la vascularisation.

Après la fracture la réponse vasculaire augmente progressivement à partir du 3ème jour, atteint un maximum à la fin de la 2ème semaine puis diminue progressivement. Les capillaires se développent au niveau du foyer de fracture au cours de la 2ème semaine. En l'absence de plâtre (groupe 1) la dilatation de l'artère principale est suivie d'une prolifération des vaisseaux, petits et moyens, ainsi que des capillaires, qui persiste jusqu'à la 10ème semaine. Dans le groupe 2 (avec plâtre) le système vasculaire revient à la normale dès la 7ème semaine. Des cals exubérants et des retards de consolidation ont été observés dans le groupe 1 alors qu'une consolidation précoce avec formation de cal modéré est la règle dans le groupe 2.

This is a preview of subscription content, log in to check access.

References

  1. 1

    Geiser M, Trueta J (1958) Muscle action, bone refraction and bone formation. J Bone Joint Surg (Br) 40:282–311

  2. 2

    Gothman L (1961) Vascular reaction in experimental fractures: microangiographic and radioisotope studies. Acta Chir Scand, Suppl 284

  3. 3

    Gothman L (1961) The arterial pattern of the rabbit tibia after the application of an intramedullary nail. A microangiographic study. Acta Chir Scand, 120:211, 196

  4. 4

    Gothman L (1962) Local arterial changes associated with experimental fracture of rabbit's tibia treated with encircling wires. A microangiographic study Acta Chir Scand, 123:17

  5. 5

    Kolodny A (1923) The periosteal blood supply of healing fractures. J Bone Joint Surg 5:698

  6. 6

    Lauren EL, Kelly PJ (1969) Blood flow, oxygen consumption carbondioxide production and blood calcium changes in tibial fractures in dogs. J Bone Joint Surg (Am) 51:299–308

  7. 7

    Mohanti RC (1973) An experimental study of vascular response healing of fractures of tenotomised limbs Surg Gynaec and Obst 137:821

  8. 8

    Mohanti RC (1976) Spalteholtz technique in the study of open fractures. An experimental study. Ind J Orth 2:91

  9. 9

    Rhinelander FW, Bargery RA (1962) Microangiography in bone healing. Indisplaced closed fractures. J Bone Joint Surg (Am) 44:1273–1298

  10. 10

    Spalteholtz KW (1914) Über das Durchsichtigmachen von menschlichen und tierischen Präparaten. 2. Auflage, Leipzig, S Hirzel

  11. 11

    Trueta J, et al (1947) Studies of the renal circulation. Oxford Blackwell Scientific Publication

  12. 12

    Urist MR, McLean FC (1941) Calification and ossification. J Bone Joint Surg 23:1

  13. 13

    Wray JB (1964) Acute changes in femoral arterial blood flow after closed tibial fractures in dogs. J Bone Joint Surg (Am) 46:1262–1268

  14. 14

    Wray JB, Lynch CJ (1959) The vascular response to fractured tibia in rats. J Bone Joint Surg (Am) 41:1143–1148

  15. 15

    Wray JB (1961) The vascular response in repeated fractures. Surg Gynaec and Obst 112:421

  16. 16

    Yamagashi M, Yashimura Y (1955) Biochemanics of fracture healing. J Bone Joint Surg (Am) 37:1035–1068

Download references

Author information

Correspondence to R. C. Mohanti.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mohanti, R.C., Mahakul, N.C. Vascular response in fractured limbs with and without immobilisation: An experimental study on rabbits. International Orthopaedics 7, 173–177 (1983). https://doi.org/10.1007/BF00269502

Download citation

Key words

  • Vascular response
  • Fracture
  • Rabbit limbs
  • Immobilisation